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Fakhoury H, Tamim H, Ferwana M, et al. Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS. J Family Med Prim Care. 2012;1(2):132-6doi: 10.4103/2249-4863.104984.
Fakhoury, H., Tamim, H., Ferwana, M., Siddiqui, I. A., Adham, M., & Tamimi, W. (2012). Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS. Journal of family medicine and primary care, 1(2), 132-6. https://doi.org/10.4103/2249-4863.104984
Fakhoury, Hana, et al. "Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS." Journal of family medicine and primary care vol. 1,2 (2012): 132-6. doi: https://doi.org/10.4103/2249-4863.104984
Fakhoury H, Tamim H, Ferwana M, Siddiqui IA, Adham M, Tamimi W. Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS. J Family Med Prim Care. 2012 Jul;1(2):132-6. doi: 10.4103/2249-4863.104984. PMID: 24479022; PMCID: PMC3893977.
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J Family Med Prim Care. 2012 Jul;1(2):132-6. doi: 10.4103/2249-4863.104984.

Age and BMI Adjusted Comparison of Reproductive Hormones in PCOS.

Journal of family medicine and primary care

Hana Fakhoury, Hani Tamim, Mazen Ferwana, Imran A Siddiqui, Maysoon Adham, Waleed Tamimi

Affiliations

  1. Department of Basic Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
  2. Department of Obstetrics and Gynecology, National Guard Health Affairs, Riyadh, Saudi Arabia.

PMID: 24479022 PMCID: PMC3893977 DOI: 10.4103/2249-4863.104984

Abstract

OBJECTIVE AND BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex condition and has been described in women who have polycystic ovaries as the underlying cause of hirsutism and chronic anovulation. Studies on PCOS in the Saudi population are very few. The aim of this study was to investigate the reproductive hormones levels in patients with PCOS. Effect of age and body mass index (BMI) on the hormonal findings was eliminated through a multivariate analysis.

MATERIALS AND METHODS: A comparative study was conducted on Saudi subjects attending the outpatient clinic of National Guard Hospital in Riyadh. A total of 62 cases with PCOS and 40 healthy Saudi women were included in this study. Physical evaluation and laboratory investigations were carried out. Blood luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2), dehydroepiandrosterone sulfate (DHEA-SO4), sex hormone-binding globulin (SHBG), total testosterone, prolactin, and progesterone were determined. To adjust for the potentially confounding effect of age and BMI, we carried out multivariate linear regression analyses for the association between each of the reproductive hormones and PCOS.

RESULTS: Serum levels of FSH, SHBG, and progesterone were significantly lower in PCOS compared to controls (respective P values 0.001, 0.001, and 0.002), while LH/FSH and testosterone levels were higher in PCOS cases than in controls (P = 0.008 and 0.003, respectively). When multivariate linear regression analyses were carried out, LH/FSH and total testosterone were positively correlated with the disease [95% confidence interval (CI) = 0.02-0.35 and 0.02-0.17, respectively], whereas FSH, SHBG, and progesterone were negatively correlated with the disease (95% CI = -0.06 to 0.001, -0.01 to 0.001, and -0.17 to -0.03, respectively), independent of age and BMI.

CONCLUSION: Our study suggests that regardless of the age and weight factors, Saudi patients with PCOS have higher levels of LH/FSH and total testosterone; but have lower levels of FSH, SHBG, and progesterone compared to controls.

Keywords: Age; Saudi Arabia; body mass index; polycystic ovary syndrome; reproductive hormones

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