Display options
Cite
Izawa H, Nishino S, Maeda H, et al. Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process. Carbohydr Polym. 2013;102:846-51doi: 10.1016/j.carbpol.2013.10.080.
Izawa, H., Nishino, S., Maeda, H., Morita, K., Ifuku, S., Morimoto, M., Saimoto, H., & Kadokawa, J. (2014). Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process. Carbohydrate polymers, 102846-51. https://doi.org/10.1016/j.carbpol.2013.10.080
Izawa, Hironori, et al. "Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process." Carbohydrate polymers vol. 102 (2014): 846-51. doi: https://doi.org/10.1016/j.carbpol.2013.10.080
Izawa H, Nishino S, Maeda H, Morita K, Ifuku S, Morimoto M, Saimoto H, Kadokawa J. Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process. Carbohydr Polym. 2014 Feb 15;102:846-51. doi: 10.1016/j.carbpol.2013.10.080. Epub 2013 Nov 05. PMID: 24507355.
Copy Download .nbib Format: NLM
Share it on

Carbohydr Polym. 2014 Feb 15;102:846-51. doi: 10.1016/j.carbpol.2013.10.080. Epub 2013 Nov 05.

Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process.

Carbohydrate polymers

Hironori Izawa, Shoji Nishino, Hiroyuki Maeda, Kohei Morita, Shinsuke Ifuku, Minoru Morimoto, Hiroyuki Saimoto, Jun-ichi Kadokawa

Affiliations

  1. Graduate School of Engineering, Tottori University, 4-101 Koyama-Minami, Tottori 680-8550, Japan. Electronic address: [email protected].
  2. Graduate School of Engineering, Tottori University, 4-101 Koyama-Minami, Tottori 680-8550, Japan.
  3. Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan; Research Center for Environmentally Friendly Materials Engineering, Muroran Institute of Technology, 27-1 Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.

PMID: 24507355 DOI: 10.1016/j.carbpol.2013.10.080

Abstract

We previously reported a xanthan gum (Xan) hydrogel showing excellent mechanical properties. Mineralization of hydroxyapatite (Hap) upon the Xan hydrogel would provide a unique biomaterial applicable for bone tissue engineering. Here, we show the mineralization of Hap upon the Xan hydrogel by means of an alternate soaking process. Hap was gradually grown upon the Xan-matrix surface with increasing number of soaking cycles due to the ionic interactions between calcium cations and carboxyl groups. Interestingly, the mineralization induced a microstructure change in the gel-matrix from a layered structure to a porous structure. The mechanical properties of the resulting Hap-Xan composite hydrogels were further investigated by a tensile test, where the Hap-Xan composite hydrogel with an appropriate amount of Hap (Xan/Hap=2.7) was capable of approximately 370% elongation.

Copyright © 2013 Elsevier Ltd. All rights reserved.

Keywords: Alternate soaking process; Hydroxyapatite; Inorganic–organic composite hydrogel; Mineralization; Xanthan gum

Publication Types