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Khabour OF, Fararjeh AS, Alfaouri AA. Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men. Int J Mol Epidemiol Genet. 2014;5(1):47-50
Khabour, O. F., Fararjeh, A. S., & Alfaouri, A. A. (2014). Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men. International journal of molecular epidemiology and genetics, 5(1), 47-50.
Khabour, Omar F, et al. "Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men." International journal of molecular epidemiology and genetics vol. 5,1 (2014): 47-50.
Khabour OF, Fararjeh AS, Alfaouri AA. Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men. Int J Mol Epidemiol Genet. 2014 Feb 17;5(1):47-50. eCollection 2014. PMID: 24596596; PMCID: PMC3939006.
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Int J Mol Epidemiol Genet. 2014 Feb 17;5(1):47-50. eCollection 2014.

Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men.

International journal of molecular epidemiology and genetics

Omar F Khabour, Abdulfattah S Fararjeh, Almuthana A Alfaouri

Affiliations

  1. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology Irbid 22110, Jordan.
  2. King Hussein Medical Center Amman, Jordan.

PMID: 24596596 PMCID: PMC3939006

Abstract

The azoospermia factor (AZF) region of the human Y chromosome contains essential genes for spermatogenesis. Microdeletions in AZF region has been shown to cause male infertility. The aim of this investigation was to determine the frequency of AZF microdeletions in Jordanian infertile males. A sample of 100 infertile males (36 with azoospermia and 64 with oligozoospermia) was screened for microdeletions using 16 AZF markers and polymerase chain reaction (PCR) technique. Two subjects were found to have microdeletions in AZFc region and one subject has microdeletion that includes AZFb and part of AZFc and AZFa. The three deletions were found in azoospermic subjects (8.3%). No microdeletions were found in oligozoospermic group. The frequency of AZF microdeletions in Jordanian azoospermic infertile males is comparable to that observed in other populations (1%-15%). The results suggest the importance of AZF microdeletion analysis for genetic counseling prior to providing assisted reproduction technique.

Keywords: AZF; Jordan; infertility; male; microdeletion

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