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Liedtke C, Bernemann C, Kiesel L, et al. Genomic profiling in triple-negative breast cancer. Breast Care (Basel). 2013;8(6):408-13doi: 10.1159/000357534.
Liedtke, C., Bernemann, C., Kiesel, L., & Rody, A. (2013). Genomic profiling in triple-negative breast cancer. Breast care (Basel, Switzerland), 8(6), 408-13. https://doi.org/10.1159/000357534
Liedtke, Cornelia, et al. "Genomic profiling in triple-negative breast cancer." Breast care (Basel, Switzerland) vol. 8,6 (2013): 408-13. doi: https://doi.org/10.1159/000357534
Liedtke C, Bernemann C, Kiesel L, Rody A. Genomic profiling in triple-negative breast cancer. Breast Care (Basel). 2013 Dec;8(6):408-13. doi: 10.1159/000357534. PMID: 24550748; PMCID: PMC3919434.
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Breast Care (Basel). 2013 Dec;8(6):408-13. doi: 10.1159/000357534.

Genomic profiling in triple-negative breast cancer.

Breast care (Basel, Switzerland)

Cornelia Liedtke, Christof Bernemann, Ludwig Kiesel, Achim Rody

Affiliations

  1. Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein/Campus Lübeck, Germany.
  2. Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Münster, Germany.

PMID: 24550748 PMCID: PMC3919434 DOI: 10.1159/000357534

Abstract

Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of overexpression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.

Keywords: Heterogeneity; RNA profiling; Triple negative breast cancer, subtypes; Whole genome sequencing

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