Display options
Cite
De Biase C, De Rosa R, Luciano R, et al. Effects of physical activity on endothelial progenitor cells (EPCs). Front Physiol. 2014;4:414doi: 10.3389/fphys.2013.00414.
De Biase, C., De Rosa, R., Luciano, R., De Luca, S., Capuano, E., Trimarco, B., & Galasso, G. (2013). Effects of physical activity on endothelial progenitor cells (EPCs). Frontiers in physiology, 4414. https://doi.org/10.3389/fphys.2013.00414
De Biase, Chiara, et al. "Effects of physical activity on endothelial progenitor cells (EPCs)." Frontiers in physiology vol. 4 (2013): 414. doi: https://doi.org/10.3389/fphys.2013.00414
De Biase C, De Rosa R, Luciano R, De Luca S, Capuano E, Trimarco B, Galasso G. Effects of physical activity on endothelial progenitor cells (EPCs). Front Physiol. 2014 Feb 03;4:414. doi: 10.3389/fphys.2013.00414. eCollection 2013. PMID: 24550833; PMCID: PMC3909827.
Copy Download .nbib Format: NLM
Share it on

Front Physiol. 2014 Feb 03;4:414. doi: 10.3389/fphys.2013.00414. eCollection 2013.

Effects of physical activity on endothelial progenitor cells (EPCs).

Frontiers in physiology

Chiara De Biase, Roberta De Rosa, Rossella Luciano, Stefania De Luca, Ernesto Capuano, Bruno Trimarco, Gennaro Galasso

Affiliations

  1. Department of Advanced Biomedical Sciences, "Federico II" University of Naples Naples, Italy.

PMID: 24550833 PMCID: PMC3909827 DOI: 10.3389/fphys.2013.00414

Abstract

Physical activity has a therapeutic role in cardiovascular disease (CVD), through its beneficial effects on endothelial function and cardiovascular system. Circulating endothelial progenitor cells (EPCs) are bone marrow (BM) derived cells that represent a novel therapeutic target in CVD patients, because of their ability to home to sites of ischemic injury and repair the damaged vessels. Several studies show that physical activity results in a significant increase in circulating EPCs, and, in particular, there are some evidence of the beneficial exercise-induced effects on EPCs activity in CVD settings, including coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD). The aim of this paper is to review the current evidence about the beneficial effects of physical exercise on endothelial function and EPCs levels and activity in both healthy subjects and patients with CVD.

Keywords: bone marrow; cardiovascular disease; coronary artery disease; endothelial progenitor cell; physical activity

References

  1. Angiogenesis. 2008;11(3):289-99 - PubMed
  2. Science. 1997 Feb 14;275(5302):964-7 - PubMed
  3. N Engl J Med. 2005 Sep 8;353(10):999-1007 - PubMed
  4. J Appl Physiol (1985). 2007 Mar;102(3):847-52 - PubMed
  5. Circulation. 1995 Apr 1;91(7):1981-7 - PubMed
  6. J Am Coll Cardiol. 2005 May 3;45(9):1441-8 - PubMed
  7. Nat Med. 2003 Nov;9(11):1370-6 - PubMed
  8. Mol Cell Biol. 1996 Sep;16(9):4604-13 - PubMed
  9. J Card Fail. 2007 Nov;13(9):701-8 - PubMed
  10. J Thromb Haemost. 2009 Nov;7(11):1920-8 - PubMed
  11. Circ J. 2013;77(7):1777-82 - PubMed
  12. J Clin Invest. 1999 May;103(9):1231-6 - PubMed
  13. Circ Res. 2013 Mar 29;112(7):1026-34 - PubMed
  14. N Engl J Med. 2003 Feb 13;348(7):593-600 - PubMed
  15. Circulation. 2004 Sep 7;110(10):1209-12 - PubMed
  16. Basic Res Cardiol. 2010 Sep;105(5):665-76 - PubMed
  17. Circ J. 2008 Jun;72(6):897-901 - PubMed
  18. Blood. 2000 Feb 1;95(3):952-8 - PubMed
  19. Circ Res. 2001 Jul 6;89(1):E1-7 - PubMed
  20. J Clin Invest. 2000 Jun;105(11):1631-9 - PubMed
  21. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H369-74 - PubMed
  22. Nat Med. 2007 Mar;13(3):315-23 - PubMed
  23. J Hematol Oncol. 2011 May 24;4:24 - PubMed
  24. Free Radic Biol Med. 1987;3(1):3-7 - PubMed
  25. Circulation. 1999 Nov 9;100(19):1983-91 - PubMed
  26. Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1584-95 - PubMed
  27. Annu Rev Med. 1997;48:489-509 - PubMed
  28. Hypertension. 1996 Apr;27(4):849-53 - PubMed
  29. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2850-60 - PubMed
  30. Circulation. 2005 Jan 25;111(3):288-94 - PubMed
  31. Heart. 2005 May;91(5):646-51 - PubMed
  32. J Physiol. 2003 Jan 1;546(Pt 1):289-98 - PubMed
  33. N Engl J Med. 1999 Jan 14;340(2):115-26 - PubMed
  34. J Am Coll Cardiol. 2008 Oct 21;52(17):1381-8 - PubMed
  35. Med Sci Sports Exerc. 2013 Apr;45(4):644-53 - PubMed
  36. Circulation. 2003 Mar 11;107(9):1322-8 - PubMed
  37. J Clin Invest. 1999 May;103(9):1227-30 - PubMed
  38. Int J Cardiol. 2013 May 10;165(2):247-54 - PubMed
  39. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1094-103 - PubMed
  40. Circulation. 2002 Jul 16;106(3):349-55 - PubMed
  41. Eur J Appl Physiol. 2011 Sep;111(9):2375-9 - PubMed
  42. Int J Cardiol. 2011 Feb 3;146(3):399-403 - PubMed
  43. Int J Cardiol. 2013 Sep 1;167(5):1854-9 - PubMed
  44. J Am Coll Cardiol. 2004 Jun 16;43(12):2314-8 - PubMed
  45. Int J Cardiol. 2013 Sep 1;167(5):2189-95 - PubMed
  46. Curr Pharm Des. 2012;18(2):186-91 - PubMed
  47. J Clin Invest. 2001 Aug;108(3):391-7 - PubMed
  48. Clin Res Cardiol. 2013 Apr;102(4):249-57 - PubMed
  49. Monaldi Arch Chest Dis. 2012 Sep;78(3):120-8 - PubMed
  50. Hypertension. 2005 Jul;46(1):7-18 - PubMed
  51. Int J Cardiol. 2013 Aug 10;167(3):757-61 - PubMed
  52. Circulation. 2001 Jun 12;103(23):2839-44 - PubMed
  53. J Appl Physiol (1985). 2008 Apr;104(4):1006-13 - PubMed
  54. Trends Cardiovasc Med. 2002 Feb;12(2):88-96 - PubMed
  55. Circ Res. 2004 Mar 19;94(5):573-4 - PubMed
  56. Med Sci Sports Exerc. 2012 Jan;44(1):39-49 - PubMed
  57. J Mol Cell Cardiol. 2011 May;50(5):785-92 - PubMed
  58. Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):684-90 - PubMed
  59. Front Physiol. 2013 Aug 12;4:209 - PubMed
  60. Circ Heart Fail. 2010 Jul;3(4):486-94 - PubMed
  61. Circ Res. 2005 Nov 25;97(11):1182-9 - PubMed
  62. Front Biosci. 2008 Jan 01;13:336-46 - PubMed
  63. Atherosclerosis. 2008 Dec;201(2):440-6 - PubMed
  64. Eur Heart J. 2009 Apr;30(8):890-9 - PubMed
  65. Circulation. 2002 Jun 25;105(25):3017-24 - PubMed
  66. J Transl Med. 2009 Jun 08;7:41 - PubMed
  67. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1596-603 - PubMed
  68. Hypertension. 2005 Mar;45(3):321-5 - PubMed
  69. Blood. 1998 Jul 15;92(2):362-7 - PubMed
  70. Transl Med UniSa. 2011 Oct 17;1:213-28 - PubMed
  71. Circulation. 1999 Jun 8;99(22):2871-5 - PubMed
  72. Circulation. 2004 Jan 20;109(2):220-6 - PubMed
  73. Am Heart J. 2007 Aug;154(2):352-60 - PubMed
  74. Cardiovasc Res. 2008 May 1;78(2):385-94 - PubMed
  75. Atherosclerosis. 2011 Jul;217(1):240-8 - PubMed
  76. J Gerontol A Biol Sci Med Sci. 2007 May;62(5):471-80 - PubMed
  77. Circulation. 2005 Jun 28;111(25):3391-9 - PubMed
  78. Circ Res. 2006 Feb 3;98(2):254-61 - PubMed
  79. Circulation. 2003 Jun 24;107(24):3093-100 - PubMed
  80. J Gerontol A Biol Sci Med Sci. 2010 Jul;65(7):758-63 - PubMed
  81. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1798-805 - PubMed
  82. Clin Res Cardiol. 2009 Mar;98(3):179-88 - PubMed
  83. Circulation. 2000 Sep 19;102(12):1351-7 - PubMed
  84. Br J Pharmacol. 2008 Mar;153(5):936-46 - PubMed
  85. Cell. 1994 Sep 23;78(6):919-25 - PubMed
  86. Eur J Cardiovasc Prev Rehabil. 2005 Aug;12(4):407-14 - PubMed
  87. Am J Phys Med Rehabil. 2013 Nov;92(11):1020-30 - PubMed
  88. Nature. 1995 Sep 21;377(6546):239-42 - PubMed

Publication Types