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Dang TN, Lim NK, Grubman A, et al. Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Front Aging Neurosci. 2014;6:15doi: 10.3389/fnagi.2014.00015.
Dang, T. N., Lim, N. K., Grubman, A., Li, Q. X., Volitakis, I., White, A. R., & Crouch, P. J. (2014). Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Frontiers in aging neuroscience, 615. https://doi.org/10.3389/fnagi.2014.00015
Dang, Theresa N T, et al. "Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis." Frontiers in aging neuroscience vol. 6 (2014): 15. doi: https://doi.org/10.3389/fnagi.2014.00015
Dang TN, Lim NK, Grubman A, Li QX, Volitakis I, White AR, Crouch PJ. Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Front Aging Neurosci. 2014 Feb 11;6:15. doi: 10.3389/fnagi.2014.00015. eCollection 2014. PMID: 24575040; PMCID: PMC3920072.
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Front Aging Neurosci. 2014 Feb 11;6:15. doi: 10.3389/fnagi.2014.00015. eCollection 2014.

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Frontiers in aging neuroscience

Theresa N T Dang, Nastasia K H Lim, Alexandra Grubman, Qiao-Xin Li, Irene Volitakis, Anthony R White, Peter J Crouch

Affiliations

  1. Department of Pathology, The University of Melbourne VIC, Australia.
  2. Florey Institute of Neuroscience and Mental Health, The University of Melbourne VIC, Australia.
  3. Department of Pathology, The University of Melbourne VIC, Australia ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne VIC, Australia.

PMID: 24575040 PMCID: PMC3920072 DOI: 10.3389/fnagi.2014.00015

Abstract

Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ceriod lipofuscinosis. While the definitive pathogenesis of neurodegenerative disease in humans remains to be fully elucidated, disease-like symptoms in the mouse models are all driven by the presence or over-expression of a putative pathogenic protein, indicating an in vivo relationship between expression of these proteins, disrupted metal homeostasis and the symptoms of neuronal failure. Recently it was established that mutant TAR DNA binding protein-43 (TDP-43) is associated with the development of frontotemporal lobar degeneration and ALS. Subsequent development of transgenic mice that express human TDP-43 carrying the disease-causing A315T mutation has provided new opportunity to study the underlying mechanisms of TDP-43-related neurodegenerative disease. We assessed the cognitive and locomotive phenotype of TDP-43 (A315T) mice and their wild-type littermates and also assessed bulk metal content of brain and spinal cord tissues. Metal levels in the brain were not affected by the expression of mutant TDP-43, but zinc, copper, and manganese levels were all increased in the spinal cords of TDP-43 (A315T) mice when compared to wild-type littermates. Performance of the TDP-43 (A315T) mice in the Y-maze test for cognitive function was not significantly different to wild-type mice. By contrast, performance of the TDP-43 (A315T) in the rotarod test for locomotive function was consistently worse than wild-type mice. These preliminary in vivo data are the first to show that expression of a disease-causing form of TDP-43 is sufficient to disrupt metal ion homeostasis in the central nervous system. Disrupted metal ion homeostasis in the spinal cord but not the brain may explain why the TDP-43 (A315T) mice show symptoms of locomotive decline and not cognitive decline.

Keywords: TAR DNA binding protein-43 (TDP-43); amyotrophic lateral sclerosis (ALS); copper (Cu); frontotemporal lobar degeneration (FTLD); manganese (Mn); neurodegenerative disease; zinc (Zn)

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