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Rosenwald M, Wolfrum C. The origin and definition of brite versus white and classical brown adipocytes. Adipocyte. 2013;3(1):4-9doi: 10.4161/adip.26232.
Rosenwald, M., & Wolfrum, C. (2014). The origin and definition of brite versus white and classical brown adipocytes. Adipocyte, 3(1), 4-9. https://doi.org/10.4161/adip.26232
Rosenwald, Matthias, and Wolfrum, Christian. "The origin and definition of brite versus white and classical brown adipocytes." Adipocyte vol. 3,1 (2014): 4-9. doi: https://doi.org/10.4161/adip.26232
Rosenwald M, Wolfrum C. The origin and definition of brite versus white and classical brown adipocytes. Adipocyte. 2014 Jan 01;3(1):4-9. doi: 10.4161/adip.26232. Epub 2013 Aug 28. PMID: 24575363; PMCID: PMC3917931.
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Adipocyte. 2014 Jan 01;3(1):4-9. doi: 10.4161/adip.26232. Epub 2013 Aug 28.

The origin and definition of brite versus white and classical brown adipocytes.

Adipocyte

Matthias Rosenwald, Christian Wolfrum

Affiliations

  1. Institute of Food Nutrition and Health; ETH Zürich; Schwerzenbach, Switzerland.

PMID: 24575363 PMCID: PMC3917931 DOI: 10.4161/adip.26232

Abstract

White adipose tissue stores energy while brown adipose tissue contributes to body temperature maintenance through non-shivering thermogenesis. In addition, brite (brown-in-white) adipocytes resembling classical brown adipocytes within predominantly white adipose tissue can be found in response to cold adaptation or other stimuli. Even though our understanding of brite adipocyte formation has increased substantially in the last few years, it is still unclear how brite and classical brown adipocytes are formed in vivo. In this review, we outline and discuss the current understanding of brite adipocyte nomenclature, developmental origin and possible mechanisms of their recruitment. We reason that future work in the field will bridge in vivo tracing studies and primary cell characterization with molecular mechanistic data from in vitro approaches to devise new means to increase energy expenditure.

Keywords: adipocyte FACS; beige adipocyte; bi-directional interconversion; brite adipocyte; brown adipose tissue; brown fat; browning; lineage tracing; non-shivering thermogenesis; transdifferentiation

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