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Cheema TA, Fecci PE, Ning J, et al. Immunovirotherapy for the treatment of glioblastoma. Oncoimmunology. 2014;3(1):e27218doi: 10.4161/onci.27218.
Cheema, T. A., Fecci, P. E., Ning, J., & Rabkin, S. D. (2014). Immunovirotherapy for the treatment of glioblastoma. Oncoimmunology, 3(1), e27218. https://doi.org/10.4161/onci.27218
Cheema, Tooba A, et al. "Immunovirotherapy for the treatment of glioblastoma." Oncoimmunology vol. 3,1 (2014): e27218. doi: https://doi.org/10.4161/onci.27218
Cheema TA, Fecci PE, Ning J, Rabkin SD. Immunovirotherapy for the treatment of glioblastoma. Oncoimmunology. 2014 Jan 01;3(1):e27218. doi: 10.4161/onci.27218. PMID: 24575383; PMCID: PMC3929360.
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Oncoimmunology. 2014 Jan 01;3(1):e27218. doi: 10.4161/onci.27218.

Immunovirotherapy for the treatment of glioblastoma.

Oncoimmunology

Tooba A Cheema, Peter E Fecci, Jianfang Ning, Samuel D Rabkin

Affiliations

  1. Brain Tumor Research Center; Department of Neurosurgery; Massachusetts General Hospital and Harvard Medical School; Boston, MA USA ; Momenta Pharmaceuticals; Cambridge, MA USA.
  2. Brain Tumor Research Center; Department of Neurosurgery; Massachusetts General Hospital and Harvard Medical School; Boston, MA USA.

PMID: 24575383 PMCID: PMC3929360 DOI: 10.4161/onci.27218

Abstract

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12.

Keywords: Treg; cancer stem cells; glioma; herpes simplex virus; interleukin-12; oncolytic virus

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