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Shimizu J, Kaneko F, Suzuki N. Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease. Genet Res Int. 2013;2013:363859doi: 10.1155/2013/363859.
Shimizu, J., Kaneko, F., & Suzuki, N. (2013). Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease. Genetics research international, 2013363859. https://doi.org/10.1155/2013/363859
Shimizu, Jun, et al. "Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease." Genetics research international vol. 2013 (2013): 363859. doi: https://doi.org/10.1155/2013/363859
Shimizu J, Kaneko F, Suzuki N. Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease. Genet Res Int. 2013;2013:363859. doi: 10.1155/2013/363859. Epub 2013 Dec 30. PMID: 24490076; PMCID: PMC3892938.
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Genet Res Int. 2013;2013:363859. doi: 10.1155/2013/363859. Epub 2013 Dec 30.

Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet's Disease.

Genetics research international

Jun Shimizu, Fumio Kaneko, Noboru Suzuki

Affiliations

  1. Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
  2. Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

PMID: 24490076 PMCID: PMC3892938 DOI: 10.1155/2013/363859

Abstract

Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. Recently, we found that Th17 cells, a new helper T (Th) cell subset, were increased in patients with BD, and both Th type 1 (Th1) and Th17 cell differentiation signaling pathways were overactivated. Several researches revealed that genetic polymorphisms in Th1/Th17 cell differentiation signaling pathways were associated with the onset of BD. Here, we summarize current findings on the Th cell subsets, their contribution to the pathogenesis of BD and the genetic backgrounds, especially in view of IL-12 family cytokine production and pattern recognition receptors of macrophages/monocytes.

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