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May CA. Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse. ISRN Ophthalmol. 2012;2012:378641doi: 10.5402/2012/378641.
May, C. A. (2012). Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse. ISRN ophthalmology, 2012378641. https://doi.org/10.5402/2012/378641
May, Christian Albrecht. "Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse." ISRN ophthalmology vol. 2012 (2012): 378641. doi: https://doi.org/10.5402/2012/378641
May CA. Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse. ISRN Ophthalmol. 2012 Aug 08;2012:378641. doi: 10.5402/2012/378641. eCollection 2012. PMID: 24555126; PMCID: PMC3912598.
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ISRN Ophthalmol. 2012 Aug 08;2012:378641. doi: 10.5402/2012/378641. eCollection 2012.

Distribution of nidogen in the murine eye and ocular phenotype of the nidogen-1 knockout mouse.

ISRN ophthalmology

Christian Albrecht May

Affiliations

  1. Department of Anatomy, Faculty of Medicine Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.

PMID: 24555126 PMCID: PMC3912598 DOI: 10.5402/2012/378641

Abstract

Distribution and lack of nidogen-1, part of numerous basement membranes, were studied in the mouse eye. For that purpose, eyes of C57BL/6 and nidogen-1 knockout mice were stained immunohistochemically for nidogen-1, and intraocular pressure measurements and light- and electron microscopy were used to study the nidogen-1 knockout animals. In normal mice, nidogen-1 was present in many basement membranes, but showed irregularities underneath the corneal epithelium, in Bruch's membrane and in the iris. Homozygous knockout of nidogen-1 in the mouse showed only mild pathological changes. In the anterior eye segment, small interruptions were noted in the nonpigmented ciliary epithelium without further consequences. In the posterior eye segment, interruptions of the inner limiting membrane led to small retinal ectopias and subsequent changes in the optic nerve. In summary, the knockout of nidogen-1 showed mild but significant morphological changes pointing to the importance of this protein which can in part, but not completely; be replaced by nidogen-2.

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