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Koh ES, Kim SJ, Yoon HE, et al. Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population. BMC Endocr Disord. 2014;14:24doi: 10.1186/1472-6823-14-24.
Koh, E. S., Kim, S. J., Yoon, H. E., Chung, J. H., Chung, S., Park, C. W., Chang, Y. S., & Shin, S. J. (2014). Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population. BMC endocrine disorders, 1424. https://doi.org/10.1186/1472-6823-14-24
Koh, Eun Sil, et al. "Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population." BMC endocrine disorders vol. 14 (2014): 24. doi: https://doi.org/10.1186/1472-6823-14-24
Koh ES, Kim SJ, Yoon HE, Chung JH, Chung S, Park CW, Chang YS, Shin SJ. Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population. BMC Endocr Disord. 2014 Mar 08;14:24. doi: 10.1186/1472-6823-14-24. PMID: 24606630; PMCID: PMC3973834.
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BMC Endocr Disord. 2014 Mar 08;14:24. doi: 10.1186/1472-6823-14-24.

Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population.

BMC endocrine disorders

Eun Sil Koh, Sung Jun Kim, Hye Eun Yoon, Jong Hee Chung, Sungjin Chung, Cheol Whee Park, Yoon Sik Chang, Seok Joon Shin

Affiliations

  1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seoul 137-701, Republic of Korea. [email protected].

PMID: 24606630 PMCID: PMC3973834 DOI: 10.1186/1472-6823-14-24

Abstract

BACKGROUND: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population.

METHODS: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke.

RESULTS: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46-0.92) for diabetes and 0.589 (95% CI: 0.39-0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02).

CONCLUSION: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.

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