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De Paschale M, Ceriani C, Cerulli T, et al. Antenatal screening for Toxoplasma gondii, Cytomegalovirus, rubella and Treponema pallidum infections in northern Benin. Trop Med Int Health. 2014;19(6):743-746doi: 10.1111/tmi.12296.
De Paschale, M., Ceriani, C., Cerulli, T., Cagnin, D., Cavallari, S., Cianflone, A., Diombo, K., Ndayaké, J., Aouanou, G., Zaongo, D., Priuli, G., Viganò, P., & Clerici, P. (2014). Antenatal screening for Toxoplasma gondii, Cytomegalovirus, rubella and Treponema pallidum infections in northern Benin. Tropical medicine & international health : TM & IH, 19(6), 743-746. https://doi.org/10.1111/tmi.12296
De Paschale, Massimo, et al. "Antenatal screening for Toxoplasma gondii, Cytomegalovirus, rubella and Treponema pallidum infections in northern Benin." Tropical medicine & international health : TM & IH vol. 19,6 (2014): 743-746. doi: https://doi.org/10.1111/tmi.12296
De Paschale M, Ceriani C, Cerulli T, Cagnin D, Cavallari S, Cianflone A, Diombo K, Ndayaké J, Aouanou G, Zaongo D, Priuli G, Viganò P, Clerici P. Antenatal screening for Toxoplasma gondii, Cytomegalovirus, rubella and Treponema pallidum infections in northern Benin. Trop Med Int Health. 2014 Jun;19(6):743-746. doi: 10.1111/tmi.12296. Epub 2014 Mar 10. PMID: 24612218.
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Trop Med Int Health. 2014 Jun;19(6):743-746. doi: 10.1111/tmi.12296. Epub 2014 Mar 10.

Antenatal screening for Toxoplasma gondii, Cytomegalovirus, rubella and Treponema pallidum infections in northern Benin.

Tropical medicine & international health : TM & IH

Massimo De Paschale, Cristina Ceriani, Teresa Cerulli, Debora Cagnin, Serena Cavallari, Annalisa Cianflone, Kouma Diombo, Joseph Ndayaké, Guy Aouanou, Dieudonné Zaongo, Gianbattista Priuli, Paolo Viganò, Pierangelo Clerici

Affiliations

  1. Microbiology Unit, Hospital of Legnano, Legnano, Italy.
  2. Laboratory of Experimental Biochemistry and Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milan, Italy.
  3. Hôpital Saint Jean de Dieu, Tanguiéta, Benin.
  4. Infectious Diseases Department, Hospital of Legnano, Legnano, Italy.

PMID: 24612218 DOI: 10.1111/tmi.12296

Abstract

OBJECTIVES: Toxoplasma gondii, cytomegalovirus (HCMV) and rubella virus infections are among the most serious of those contracted during pregnancy in terms of foetal consequences. Toxoplasma, HCMV and rubella antibody screening is unusual in Africa, and there are few published data. The aim of this study was to evaluate the prevalence of these markers among pregnant women in northern Benin on the occasion of routine syphilis screening.

METHODS: Toxoplasma, HCMV and rubella IgG and IgM antibodies were determined in the serum of 283 women attending Saint Jean de Dieu de Tanguiéta hospital, using an enzyme immunoassay, and IgM were confirmed using an enzyme-linked fluorescent assay (ELFA). In the case of IgM positivity, the avidity of anti-HCMV and anti-Toxoplasma IgG was measured. Total anti-Treponema pallidum antibodies were determined using an enzyme immunoassay and confirmed by immunoblotting. In the case of positivity, the Venereal Disease Research Laboratory (VDRL) test was used.

RESULTS: The prevalence of anti-Toxoplasma, anti-HCMV, anti-rubella IgG and total anti-Treponema antibodies was, respectively, 30.0%, 100%, 94% and 2.5%. The VDRL test was positive in 62.5% of the anti-Treponema-positive samples. The prevalence of anti-Toxoplasma, anti-HCMV and anti-rubella IgM was, respectively, 0.4%, 1.4% and 0%. There were no statistically significant differences in terms of age class or trimester of pregnancy. Anti-Toxoplasma and anti-HCMV IgG avidity was always high.

CONCLUSIONS: The prevalence of HCMV and rubella antibodies is high in northern Benin, whereas that of Toxoplasma antibodies is lower. As nearly two-thirds of the pregnant women were anti-Toxoplasma seronegative, antibody screening should be introduced.

© 2014 John Wiley & Sons Ltd.

Keywords: HCMV ; Toxoplasma ; VCMH ; Africa; Afrique; HCMV; Rubeola; Syphilis; Sífilis; embarazo; grossesse; pregnancy; rubella; rubéole; syphilis; África

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