Display options
Cite
Junker JP, Kamel RA, Caterson EJ, et al. Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments. Adv Wound Care (New Rochelle). 2013;2(7):348-356doi: 10.1089/wound.2012.0412.
Junker, J. P., Kamel, R. A., Caterson, E. J., & Eriksson, E. (2013). Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments. Advances in wound care, 2(7), 348-356. https://doi.org/10.1089/wound.2012.0412
Junker, Johan P E, et al. "Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments." Advances in wound care vol. 2,7 (2013): 348-356. doi: https://doi.org/10.1089/wound.2012.0412
Junker JP, Kamel RA, Caterson EJ, Eriksson E. Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments. Adv Wound Care (New Rochelle). 2013 Sep;2(7):348-356. doi: 10.1089/wound.2012.0412. PMID: 24587972; PMCID: PMC3842869.
Copy Download .nbib Format: NLM
Share it on

Adv Wound Care (New Rochelle). 2013 Sep;2(7):348-356. doi: 10.1089/wound.2012.0412.

Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments.

Advances in wound care

Johan P E Junker, Rami A Kamel, E J Caterson, Elof Eriksson

Affiliations

  1. Division of Plastic Surgery, Brigham and Women's Hospital , Harvard Medical School, Boston, Massachusetts.

PMID: 24587972 PMCID: PMC3842869 DOI: 10.1089/wound.2012.0412

Abstract

SIGNIFICANCE: Successful treatment of wounds relies on precise control and continuous monitoring of the wound-healing process. Wet or moist treatment of wounds has been shown to promote re-epithelialization and result in reduced scar formation, as compared to treatment in a dry environment.

RECENT ADVANCES: By treating wounds in a controlled wet environment, delivery of antimicrobials, analgesics, other bioactive molecules such as growth factors, as well as cells and micrografts, is allowed. The addition of growth factors or transplantation of cells yields the possibility of creating a regenerative wound microenvironment that favors healing, as opposed to excessive scar formation.

CRITICAL ISSUES: Although several manufacturers have conceived products implementing the concept of moist wound healing, there remains a lack of commercial translation of wet wound-healing principles into clinically available products. This can only be mitigated by further research on the topic.

FUTURE DIRECTIONS: The strong evidence pointing to the favorable healing of wounds in a wet or moist environment compared to dry treatment will extend the clinical indications for this treatment. Further advances are required to elucidate by which means this microenvironment can be optimized to improve the healing outcome.

References

  1. J Bone Joint Surg Am. 2009 Jan;91(1):92-8 - PubMed
  2. Growth Factors. 1992;7(1):1-14 - PubMed
  3. Nurs Times. 2003 Aug 5-11;99(31):59 - PubMed
  4. Asian J Surg. 2004 Oct;27(4):326-32 - PubMed
  5. J Eur Acad Dermatol Venereol. 2011 Feb;25(2):130-7 - PubMed
  6. J Surg Res. 1992 Jan;52(1):50-8 - PubMed
  7. J Clin Invest. 1993 Dec;92(6):2841-9 - PubMed
  8. Wound Repair Regen. 2004 Jan-Feb;12(1):44-52 - PubMed
  9. In Vivo. 2009 Nov-Dec;23(6):983-6 - PubMed
  10. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD009099 - PubMed
  11. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD009110 - PubMed
  12. Wound Repair Regen. 2009 Nov-Dec;17(6):806-16 - PubMed
  13. Wound Repair Regen. 2007 Sep-Oct;15(5):657-64 - PubMed
  14. Lancet. 1992 Jan 4;339(8784):23-5 - PubMed
  15. Diabetologia. 2003 Apr;46(4):546-55 - PubMed
  16. Ostomy Wound Manage. 2003 Oct;49(10):52-7 - PubMed
  17. Ostomy Wound Manage. 2009 Jun 1;55(6):22-8 - PubMed
  18. J Am Acad Dermatol. 1991 Dec;25(6 Pt 1):1054-8 - PubMed
  19. Wound Repair Regen. 2008 Sep-Oct;16(5):615-25 - PubMed
  20. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12188-92 - PubMed
  21. Wound Repair Regen. 2006 May-Jun;14(3):233-9 - PubMed
  22. Nature. 1962 Jan 20;193:293-4 - PubMed
  23. Cochrane Database Syst Rev. 2011 Sep 07;(9):CD009111 - PubMed
  24. Plast Reconstr Surg. 1997 Sep;100(3):657-64 - PubMed
  25. Br Med J. 1941 Jul 5;2(4200):1-7 - PubMed
  26. Int J Nurs Pract. 2003 Apr;9(2):S9-17 - PubMed
  27. J Bone Joint Surg Am. 2006 Oct;88(10):2167-74 - PubMed
  28. Dermatol Surg. 2002 Aug;28(8):755-9; discussion 759-60 - PubMed
  29. J Clin Periodontol. 1989 Sep;16(8):545-8 - PubMed
  30. Br J Community Nurs. 2003;8(9 Suppl):suppl 10-6 - PubMed
  31. J Dermatol Surg Oncol. 1992 Nov;18(11):992-5 - PubMed
  32. Wound Repair Regen. 2006 Nov-Dec;14(6):647-8 - PubMed
  33. J Invest Dermatol. 1988 Nov;91(5):434-9 - PubMed
  34. Br J Nurs. 2004 Oct 28-Nov 10;13(19):S30-6 - PubMed
  35. J Invest Dermatol. 1990 May;94(5):624-9 - PubMed
  36. Plast Reconstr Surg. 2002 Dec;110(7):1680-7 - PubMed
  37. Nature. 1963 Oct 26;200:377-8 - PubMed
  38. J Trauma. 1989 Jul;29(7):924-30; discussion 930-1 - PubMed
  39. Eplasty. 2011 Feb 16;11:e5 - PubMed
  40. Int J Low Extrem Wounds. 2003 Dec;2(4):189-97 - PubMed
  41. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9307-11 - PubMed
  42. Lancet. 1983 Sep 3;2(8349):532-4 - PubMed
  43. J Invest Dermatol. 2007 May;127(5):1030-41 - PubMed
  44. J Invest Dermatol. 1999 Mar;112(3):297-302 - PubMed
  45. Ann Surg. 2004 Jul;240(1):179-86 - PubMed
  46. J Am Coll Surg. 2011 Dec;213(6):728-35 - PubMed
  47. J Clin Invest. 1996 Dec 15;98(12):2894-902 - PubMed
  48. Aesthetic Plast Surg. 2003 Sep-Oct;27(5):411-7 - PubMed
  49. J Invest Dermatol. 1992 Dec;99(6):729-33 - PubMed
  50. Am J Surg. 1994 Jan;167(1A):2S-6S - PubMed
  51. Ann Plast Surg. 1995 May;34(5):493-9; discussion 499-500 - PubMed
  52. Ostomy Wound Manage. 1995 Aug;41(7A Suppl):37S-44S; discussion 45S - PubMed
  53. J Surg Res. 1987 Oct;43(4):322-8 - PubMed
  54. Dermatol Surg. 2001 Feb;27(2):175-81 - PubMed
  55. Cochrane Database Syst Rev. 2011 Sep 07;(9):CD009101 - PubMed
  56. Plast Reconstr Surg. 2012 Mar;129(3):443e-452e - PubMed
  57. Tech Coloproctol. 2011 Mar;15(1):75-7 - PubMed
  58. J Invest Dermatol. 1990 Dec;95(6):626-31 - PubMed
  59. Biomaterials. 1986 Jan;7(1):67-72 - PubMed
  60. Plast Reconstr Surg. 2000 Sep;106(3):602-12; discussion 613-4 - PubMed
  61. J Bone Joint Surg Am. 2007 Aug;89(8):1723-6 - PubMed
  62. Am J Pathol. 1990 Jun;136(6):1235-46 - PubMed
  63. Am J Surg. 1983 Mar;145(3):379-81 - PubMed
  64. Plast Reconstr Surg. 1991 Aug;88(2):189-94; discussion 195-6 - PubMed

Publication Types