Adv Wound Care (New Rochelle). 2013 Apr;2(3):75-80. doi: 10.1089/wound.2011.0342.
Advances in wound care
Manuela Martins-Green
PMID: 24527329 PMCID: PMC3840554 DOI: 10.1089/wound.2011.0342
BACKGROUND: Integrins are transmembrane proteins that are present in the plasma membrane of basal ketatinocytes and connect them to the underlying basement membrane and to the dermis. There are primarily two types of interactions between the epidermis and the dermis-via focal adhesion plaques and hemidesmosomes. It is critical that these interactions form properly to confer the skin strong mechanical properties. Integrins are also critical during wound healing, particularly in closure of the wound.
THE PROBLEM: Margadant
BASIC/CLINICAL SCIENCE ADVANCES: Models such as the conditional model developed by Margadant
CLINICAL CARE RELEVANCE: The model and the findings provide an opportunity to decipher mechanisms of disease and for potential development of treatments for human skin disorders and impaired healing, including chronic ulcers.
CONCLUSION: This work provides knowledge that leads to the understanding of delayed re-epithelialization during wound healing and dermal epidermal defects, blistering, and chronic skin diseases, hence providing the opportunity to understand the basic cellular and molecular mechanisms involved in these situations.
