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Emokpae MA, Adejumol BG, Abdu A, et al. Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients. Niger Med J. 2013;54(6):426-9doi: 10.4103/0300-1652.126302.
Emokpae, M. A., Adejumol, B. G., Abdu, A., & Sadiq, N. M. (2013). Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients. Nigerian medical journal : journal of the Nigeria Medical Association, 54(6), 426-9. https://doi.org/10.4103/0300-1652.126302
Emokpae, Mathias Abiodun, et al. "Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients." Nigerian medical journal : journal of the Nigeria Medical Association vol. 54,6 (2013): 426-9. doi: https://doi.org/10.4103/0300-1652.126302
Emokpae MA, Adejumol BG, Abdu A, Sadiq NM. Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients. Niger Med J. 2013 Nov;54(6):426-9. doi: 10.4103/0300-1652.126302. PMID: 24665160; PMCID: PMC3948968.
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Niger Med J. 2013 Nov;54(6):426-9. doi: 10.4103/0300-1652.126302.

Serum alpha-fetoprotein level is higher in hepatitis C than hepatitis B infected chronic liver disease patients.

Nigerian medical journal : journal of the Nigeria Medical Association

Mathias Abiodun Emokpae, Babatunde Gabriel Adejumol, Aliyu Abdu, Nasiru Magaji Sadiq

Affiliations

  1. Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Kano, Nigeria ; Department of Chemical Pathology Aminu Kano Teaching Hospital, Kano, Nigeria.
  2. Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Kano, Nigeria.
  3. Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
  4. Department of Medical Microbiology Aminu Kano Teaching Hospital, Kano, Nigeria.

PMID: 24665160 PMCID: PMC3948968 DOI: 10.4103/0300-1652.126302

Abstract

BACKGROUND: The frequency of raised serum alpha-fetoprotein may vary in relation to hepatitis B or C infection in chronic liver disease (CLD). The study evaluated the frequency of hepatitis B and C in patients with chronic liver disease and correlated the levels of serum alpha-fetoprotein with hepatitis B and C infection in the patients.

MATERIALS AND METHODS: Eighty-six patients with CLD were recruited for the study. Fifty subjects, with no CLD were used as control. Hepatitis B surface Antigen (HBsAg) and hepatitis C antibody were determined using enzyme-linked immunosorbent assay (ELISA) technique (Human diagnostics, Germany and HCV Murex 40 Anhet laboratories, USA) while liver function tests were evaluated using express plus chemistry auto analyzer. Alpha-fetoprotein was assayed using ELECSYS 1010 auto analyser.

RESULTS: There were 60 males and 26 females, with a mean age of 46 + 6.5 years, while the controls were 25 males and 25 females with a mean age of 41 ± 2.5 years. Thirty-six subjects (41.7%) were seropositive for HBsAg while 24 (27.9%) were seropositive for Hepatitis C Virus (HCV) antibody. The mean alpha fetoprotein level was 359 ± 9.9 ng/mL while mean control value was 1.93 ± 0.24 ng/mL. Liver function test parameters were elevated compared with control subjects (P < 0.001). The increase in serum alpha-fetoprotein was higher (P < 0.001) in HCV than HBsAg positive patients.

CONCLUSION: Serum alpha-fetoprotein level was highest in HCV compared to HBsAg positive and hepatitis negative patients with CLD.

Keywords: Alpha fetoprotein; HBsAg; HCV antibody; chronic liver disease

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