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Gupta S, Gupta H, Mandhyan D, et al. Bisphophonates related osteonecrosis of the jaw. Natl J Maxillofac Surg. 2013;4(2):151-8doi: 10.4103/0975-5950.127643.
Gupta, S., Gupta, H., Mandhyan, D., & Srivastava, S. (2013). Bisphophonates related osteonecrosis of the jaw. National journal of maxillofacial surgery, 4(2), 151-8. https://doi.org/10.4103/0975-5950.127643
Gupta, Swati, et al. "Bisphophonates related osteonecrosis of the jaw." National journal of maxillofacial surgery vol. 4,2 (2013): 151-8. doi: https://doi.org/10.4103/0975-5950.127643
Gupta S, Gupta H, Mandhyan D, Srivastava S. Bisphophonates related osteonecrosis of the jaw. Natl J Maxillofac Surg. 2013 Jul;4(2):151-8. doi: 10.4103/0975-5950.127643. PMID: 24665168; PMCID: PMC3961887.
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Natl J Maxillofac Surg. 2013 Jul;4(2):151-8. doi: 10.4103/0975-5950.127643.

Bisphophonates related osteonecrosis of the jaw.

National journal of maxillofacial surgery

Swati Gupta, Hemant Gupta, Devendra Mandhyan, Sanjeev Srivastava

Affiliations

  1. Department of Prosthodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
  2. Oral and Maxillofacial Surgery, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
  3. Department of Prosthodontics, Chandra Dental College and Research Centre, Lucknow, India.
  4. Department of Conservative Dentistry, Saraswati Dental College, Lucknow, Uttar Pradesh, India.

PMID: 24665168 PMCID: PMC3961887 DOI: 10.4103/0975-5950.127643

Abstract

OBJECTIVE: With sporadic reporting of BPs related osteonecrosis of jaw and in absence of definitive guidelines regarding the management of such patients, the dentists and the oral and maxillofacial surgeons need to be updated about this issue. The objective of this article was to produce an updated bibliographic review of BPs related ONJ. This paper reviews the literature regarding the same for better understanding of the problem and its management.

BACKGROUND: Bisphosphonates (BPs) are potent inhibitors of bone resorption and are widely used in the treatment of osteoporosis and other diseases that cause bone mass loss, such as Paget's disease, bone metastases, and multiple myeloma, to prevent pathological fractures. With increasing use, evidence is emerging that patients taking BP drugs are at risk of developing osteonecrosis of the jaws (ONJs), sometimes occurring spontaneously, but more commonly following dental extractions or oral bone surgery.

MATERIALS AND METHODS: A bibliographic search was carried out using PubMed, Medline, and search engines ending in April, 2013. The search terms used were: Oral BPs, dental implants, and osteonecrosis.

CONCLUSION: On the basis of available literature, the management of patients on bisphosphonates requiring dental treatment is classified according to the duration of BPs treatment, method of administration of BPs etc. Dental treatments when planned carefully in such patients have a fair to good prognosis.

Keywords: Bisphosphonate; implants; osteonecrosis of jaw

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