Display options
Cite
Cano D, Gomez CF, Ospina N, et al. Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population. ISRN Oncol. 2014;2014:530675doi: 10.1155/2014/530675.
Cano, D., Gomez, C. F., Ospina, N., Cajigas, J. A., Groot, H., Andrade, R. E., & Torres, M. M. (2014). Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population. ISRN oncology, 2014530675. https://doi.org/10.1155/2014/530675
Cano, D, et al. "Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population." ISRN oncology vol. 2014 (2014): 530675. doi: https://doi.org/10.1155/2014/530675
Cano D, Gomez CF, Ospina N, Cajigas JA, Groot H, Andrade RE, Torres MM. Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population. ISRN Oncol. 2014 Jan 28;2014:530675. doi: 10.1155/2014/530675. eCollection 2014. PMID: 24616820; PMCID: PMC3927756.
Copy Download .nbib Format: NLM
Share it on

ISRN Oncol. 2014 Jan 28;2014:530675. doi: 10.1155/2014/530675. eCollection 2014.

Mitochondrial DNA haplogroups and susceptibility to prostate cancer in a colombian population.

ISRN oncology

D Cano, C F Gomez, N Ospina, J A Cajigas, H Groot, R E Andrade, M M Torres

Affiliations

  1. Human Genetics Laboratory, Science Faculty, Universidad de los Andes, Bogotá, Colombia.
  2. Prostate Clinic, Fundación Santa Fe de Bogotá University Hospital, Bogotá, Colombia.
  3. Urology Department, Hospital Militar Central, Bogotá, Colombia.
  4. Pathology and Laboratory Department, Fundación Santa Fe de Bogotá University Hospital, Bogotá, Colombia.

PMID: 24616820 PMCID: PMC3927756 DOI: 10.1155/2014/530675

Abstract

Prostate cancer (PC) is one of the most common cancers and the second leading cause of mortality from cancer in Colombian men. Mitochondrial DNA (mtDNA) haplogroups have been associated with the risk of PC. Several studies have demonstrated dramatic differences regarding the risk of PC among men from different ethnic backgrounds. The present study was aimed at assessing the relationship between mtDNA haplogroups and PC. The mitochondrial DNA hypervariable segment I (HSV-1) was sequenced in a population-based study covering 168 cases (CA) and 140 unrelated healthy individuals as a control group (CG). A total of 92 different mtDNA sequences were found in CA and 59 were found in the CG. According to the geographical origin attributed to each mtDNA haplogroup, 82% of the mtDNA sequences found in both groups were Native Americans (A, B, C, and D). The most frequent was A (41.1%CA-42.1%CG), followed by B (22.0%CA-21.4%CG), C (12.0%CA-11.4%CG), and D (6%CA-10.0%CG). A lower percentage of European haplogroups (U, H, K, J, M, T, and HV) were also found (13.1%CA-12.9%CG), likewise African haplogroups (L0, L1, L2, and L3) (6.5%CA-2.1%CG). There were no statistically significant differences between the distribution of mtDNA haplogroups in CA and the CG in this study.

References

  1. Hum Biol. 2008 Jun;80(3):203-37 - PubMed
  2. Cancer Biol Ther. 2006 Aug;5(8):967-75 - PubMed
  3. Int J Cancer. 1999 Apr 12;81(2):219-24 - PubMed
  4. Biochem Biophys Res Commun. 2005 Sep 30;335(3):891-9 - PubMed
  5. Cancer Lett. 2007 May 8;249(2):249-55 - PubMed
  6. PLoS One. 2008 Mar 12;3(3):e1764 - PubMed
  7. Hum Mutat. 2009 Feb;30(2):E386-94 - PubMed
  8. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1661-7 - PubMed
  9. J Clin Pathol. 2006 Jan;59(1):10-6 - PubMed
  10. Am J Hum Genet. 2000 Nov;67(5):1287-95 - PubMed
  11. BMC Genomics. 2006 Jul 21;7:185 - PubMed
  12. J Urol. 2006 Nov;176(5):2308-9; author reply 2309 - PubMed
  13. Science. 2000 Mar 17;287(5460):2017-9 - PubMed
  14. Nat Genet. 2006 Jun;38(6):652-8 - PubMed
  15. Am J Hum Genet. 2000 Aug;67(2):444-61 - PubMed
  16. J Biol Chem. 1997 Oct 10;272(41):25409-12 - PubMed
  17. Am J Hum Genet. 2004 Mar;74(3):454-65 - PubMed
  18. PLoS One. 2009 Jul 28;4(7):e6370 - PubMed
  19. Am J Hum Genet. 2002 Nov;71(5):1150-60 - PubMed
  20. Methods Mol Biol. 2009;471:291-303 - PubMed
  21. J Aging Res. 2011 Feb 15;2011:136435 - PubMed
  22. Nature. 1981 Apr 9;290(5806):457-65 - PubMed
  23. Cancer. 2005 Mar 1;103(5):1045-53 - PubMed
  24. Am J Hum Genet. 1994 Jul;55(1):27-33 - PubMed
  25. Hum Biol. 1997 Apr;69(2):141-59 - PubMed
  26. Cancer Res. 2007 Jan 15;67(2):437-9 - PubMed
  27. Mitochondrion. 2011 Jan;11(1):27-32 - PubMed
  28. Am J Hum Genet. 2004 Sep;75(3):522-4; author reply 524-6 - PubMed
  29. Urology. 2008 Jun;71(6):1172-6 - PubMed
  30. J Hum Genet. 2006;51(12):1073-1082 - PubMed
  31. Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 - PubMed
  32. Forensic Sci Int. 2007 Oct 25;172(2-3):171-8 - PubMed
  33. Cancer Res. 2002 Nov 15;62(22):6470-4 - PubMed
  34. Electrophoresis. 2005 Sep;26(18):3414-29 - PubMed
  35. Hum Biol. 2003 Feb;75(1):13-30 - PubMed
  36. J Urol. 2006 Feb;175(2):468-72; discussion 472-3 - PubMed
  37. Carcinogenesis. 2003 Sep;24(9):1481-7 - PubMed
  38. Ann N Y Acad Sci. 2005 May;1042:109-22 - PubMed
  39. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):719-24 - PubMed
  40. Cancer Res. 2007 May 15;67(10):4687-94 - PubMed
  41. Mol Biol Evol. 2007 Aug;24(8):1596-9 - PubMed
  42. PLoS One. 2007 Sep 05;2(9):e829 - PubMed
  43. PLoS One. 2008 May 21;3(5):e2211 - PubMed
  44. PLoS Med. 2005 Nov;2(11):e296 - PubMed
  45. J Urol. 2000 Jan;163(1):137-42 - PubMed
  46. Am J Hum Genet. 2002 Nov;71(5):1082-111 - PubMed
  47. Am J Hum Genet. 2008 Mar;82(3):583-92 - PubMed
  48. Am J Phys Anthropol. 2010 Sep;143(1):13-20 - PubMed
  49. Am J Hum Biol. 2006 Jan;18(1):59-65 - PubMed

Publication Types