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Fong EL, Santoro M, Farach-Carson MC, et al. TISSUE ENGINEERING PERFUSABLE CANCER MODELS. Curr Opin Chem Eng. 2014;3:112-117doi: 10.1016/j.coche.2013.12.008.
Fong, E. L., Santoro, M., Farach-Carson, M. C., Kasper, F. K., & Mikos, A. G. (2014). TISSUE ENGINEERING PERFUSABLE CANCER MODELS. Current opinion in chemical engineering, 3112-117. https://doi.org/10.1016/j.coche.2013.12.008
Fong, E L, et al. "TISSUE ENGINEERING PERFUSABLE CANCER MODELS." Current opinion in chemical engineering vol. 3 (2014): 112-117. doi: https://doi.org/10.1016/j.coche.2013.12.008
Fong EL, Santoro M, Farach-Carson MC, Kasper FK, Mikos AG. TISSUE ENGINEERING PERFUSABLE CANCER MODELS. Curr Opin Chem Eng. 2014 Feb;3:112-117. doi: 10.1016/j.coche.2013.12.008. PMID: 24634812; PMCID: PMC3949682.
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Curr Opin Chem Eng. 2014 Feb;3:112-117. doi: 10.1016/j.coche.2013.12.008.

TISSUE ENGINEERING PERFUSABLE CANCER MODELS.

Current opinion in chemical engineering

E L Fong, M Santoro, M C Farach-Carson, F K Kasper, A G Mikos

Affiliations

  1. Department of Bioengineering, Rice University, Houston, TX 77030.
  2. Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005.
  3. Department of Bioengineering, Rice University, Houston, TX 77030 ; Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251.
  4. Department of Bioengineering, Rice University, Houston, TX 77030 ; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005.

PMID: 24634812 PMCID: PMC3949682 DOI: 10.1016/j.coche.2013.12.008

Abstract

The effect of fluid flow on cancer progression is currently not well understood, highlighting the need for perfused tumor models to close this gap in knowledge. Enabling biological processes at the cellular level to be modeled with high spatiotemporal control, microfluidic tumor models have demonstrated applicability as platforms to study cell-cell interactions, effect of interstitial flow on tumor migration and the role of vascular barrier function. To account for the multi-scale nature of cancer growth and invasion, macroscale models are also necessary. The consideration of fluid dynamics within tumor models at both the micro- and macroscopic levels may greatly improve our ability to more fully mimic the tumor microenvironment.

Keywords: Cancer; Fluid flow; Perfusion; Tissue engineering; Tumor models

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