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Fieß A, Halstenberg S, Fellas A, et al. Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report. J Med Case Rep. 2014;8:110doi: 10.1186/1752-1947-8-110.
Fieß, A., Halstenberg, S., Fellas, A., Frisch, I., & Steinhorst, U. H. (2014). Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report. Journal of medical case reports, 8110. https://doi.org/10.1186/1752-1947-8-110
Fieß, Achim, et al. "Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report." Journal of medical case reports vol. 8 (2014): 110. doi: https://doi.org/10.1186/1752-1947-8-110
Fieß A, Halstenberg S, Fellas A, Frisch I, Steinhorst UH. Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report. J Med Case Rep. 2014 Apr 02;8:110. doi: 10.1186/1752-1947-8-110. PMID: 24694257; PMCID: PMC4230808.
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J Med Case Rep. 2014 Apr 02;8:110. doi: 10.1186/1752-1947-8-110.

Anaphylactic reaction to intravenous corticosteroids in the treatment of ocular toxoplasmosis: a case report.

Journal of medical case reports

Achim Fieß, Sven Halstenberg, Antonia Fellas, Inez Frisch, Ulrich Helmut Steinhorst

Affiliations

  1. Department of Ophthalmology, Dr, Horst-Schmidt-Clinics, Wiesbaden, Germany. [email protected].

PMID: 24694257 PMCID: PMC4230808 DOI: 10.1186/1752-1947-8-110

Abstract

INTRODUCTION: This case report presents for the first time an acute systemic allergic reaction to corticosteroids in a patient with ocular toxoplasmosis after treatment with intravenous cortisone, and discusses alternative treatments.

CASE PRESENTATION: We present the case of a 57-year-old Caucasian woman with an anaphylactic reaction after intravenous injection of prednisolone-21-hydrogensuccinate (Solu-Decortin® H) given for the treatment of toxoplasmosis-associated chorioretinitis. Immediately after the injection, she developed an acute erythema of the legs and abdomen, angioedema, hypotension (blood pressure 80/40mmHg), tachycardia (heart rate 140/minute), hyperthermia (38.8°C), and respiratory distress. Allergological examinations showed a positive skin-prick test to prednisolone and methylprednisolone. In addition, an oral exposure test with dexamethasone (Fortecortin®) and betamethasone (Celestamine®) was conducted to find alternative corticosteroids for future treatments. After oral application, no local or systemic reactions were observed for these two substances.

CONCLUSIONS: This case report demonstrates that systemic allergic reactions are possible in patients with uveitis or other inflammatory ophthalmological conditions treated with intravenous corticosteroids. Intravenous administration of cortisone, for example, in the treatment of ocular toxoplasmosis, should always be conducted with caution because of a possible allergic reaction. For patients who react to a particular steroid, it is necessary to undergo allergological testing to confirm that the compound in question is indeed allergenic, and to identify other corticosteroids that are safe for future anti-inflammatory treatments.

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