Display options
Cite
Turner N, Pestrin M, Galardi F, et al. Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?. Cancers (Basel). 2014;6(2):684-707doi: 10.3390/cancers6020684.
Turner, N., Pestrin, M., Galardi, F., De Luca, F., Malorni, L., & Di Leo, A. (2014). Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?. Cancers, 6(2), 684-707. https://doi.org/10.3390/cancers6020684
Turner, Natalie, et al. "Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?." Cancers vol. 6,2 (2014): 684-707. doi: https://doi.org/10.3390/cancers6020684
Turner N, Pestrin M, Galardi F, De Luca F, Malorni L, Di Leo A. Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?. Cancers (Basel). 2014 Mar 25;6(2):684-707. doi: 10.3390/cancers6020684. PMID: 24670368; PMCID: PMC4074798.
Copy Download .nbib Format: NLM
Share it on

Cancers (Basel). 2014 Mar 25;6(2):684-707. doi: 10.3390/cancers6020684.

Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?.

Cancers

Natalie Turner, Marta Pestrin, Francesca Galardi, Francesca De Luca, Luca Malorni, Angelo Di Leo

Affiliations

  1. Sandro Pitigliani Medical Oncology Department, Prato Hospital, Istituto Toscano Tumori, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].
  2. Sandro Pitigliani Medical Oncology Department, Prato Hospital, Istituto Toscano Tumori, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].
  3. Translational Research Laboratory, Prato Hospital, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].
  4. Translational Research Laboratory, Prato Hospital, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].
  5. Sandro Pitigliani Medical Oncology Department, Prato Hospital, Istituto Toscano Tumori, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].
  6. Sandro Pitigliani Medical Oncology Department, Prato Hospital, Istituto Toscano Tumori, Via Ugo Foscolo, Prato, PO 59100, Italy. [email protected].

PMID: 24670368 PMCID: PMC4074798 DOI: 10.3390/cancers6020684

Abstract

Circulating tumor cell (CTC) count has prognostic significance in metastatic breast cancer, but the predictive utility of CTCs is uncertain. Molecular studies on CTCs have often been limited by a low number of CTCs isolated from a high background of leukocytes. Improved enrichment techniques are now allowing molecular characterisation of single CTCs, whereby molecular markers on single CTCs may provide a real-time assessment of tumor biomarker status from a blood test or "liquid biopsy", potentially negating the need for a more invasive tissue biopsy. The predictive ability of CTC biomarker analysis has predominantly been assessed in relation to HER2, with variable and inconclusive results. Limited data exist for other biomarkers, such as the estrogen receptor. In addition to the need to define and validate the most accurate and reproducible method for CTC molecular analysis, the clinical relevance of biomarkers, including gain of HER2 on CTC after HER2 negative primary breast cancer, remains uncertain. This review summarises the currently available data relating to biomarker evaluation on CTCs and its role in directing management in metastatic breast cancer, discusses limitations, and outlines measures that may enable future development of this approach.

References

  1. Breast Care (Basel). 2012 Feb;7(1):7-12 - PubMed
  2. J Cancer Res Clin Oncol. 2013 May;139(5):739-46 - PubMed
  3. Nature. 2007 Dec 20;450(7173):1235-9 - PubMed
  4. J Clin Oncol. 2008 Oct 20;26(30):4869-74 - PubMed
  5. Clin Cancer Res. 2006 Mar 15;12(6):1715-20 - PubMed
  6. Int J Cancer. 2010 May 15;126(10):2437-47 - PubMed
  7. Clin Cancer Res. 2011 Jun 1;17(11):3600-18 - PubMed
  8. Clin Breast Cancer. 2010 Oct 1;10(5):392-7 - PubMed
  9. Breast Cancer Res Treat. 2009 Dec;118(3):523-30 - PubMed
  10. N Engl J Med. 2004 Aug 19;351(8):781-91 - PubMed
  11. Breast Cancer Res Treat. 2009 Jun;115(3):581-90 - PubMed
  12. Gene. 1995 Jun 14;159(1):19-27 - PubMed
  13. Clin Cancer Res. 2008 May 1;14(9):2593-600 - PubMed
  14. Clin Cancer Res. 2006 Nov 1;12(21):6403-9 - PubMed
  15. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3970-5 - PubMed
  16. Cancer Biol Ther. 2010 Nov 1;10(9):860-4 - PubMed
  17. J Natl Cancer Inst. 2008 Aug 20;100(16):1179-83 - PubMed
  18. Breast Cancer Res. 2012 Aug 15;14(4):R118 - PubMed
  19. Eur J Cancer. 1998 May;34(6):791-808 - PubMed
  20. Histopathology. 2012 May;60(6B):E87-95 - PubMed
  21. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  22. Clin Cancer Res. 2010 May 1;16(9):2634-45 - PubMed
  23. Chin J Cancer. 2011 Jan;30(1):54-61 - PubMed
  24. Anticancer Res. 2011 Feb;31(2):427-41 - PubMed
  25. Gynecol Oncol. 2011 Aug;122(2):356-60 - PubMed
  26. Cytometry B Clin Cytom. 2011 Mar;80(2):112-8 - PubMed
  27. Cancer Metastasis Rev. 2013 Jun;32(1-2):179-88 - PubMed
  28. Clin Cancer Res. 2007 Feb 1;13(3):920-8 - PubMed
  29. Clin Chem. 2011 Sep;57(9):1242-55 - PubMed
  30. Mol Oncol. 2013 Oct;7(5):976-86 - PubMed
  31. J Clin Oncol. 2010 Feb 20;28(6):1075-83 - PubMed
  32. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10208-13 - PubMed
  33. Acta Oncol. 2011 Jun;50(5):700-10 - PubMed
  34. PLoS One. 2013 May 07;8(5):e62543 - PubMed
  35. Br J Cancer. 2010 May 11;102(10):1495-502 - PubMed
  36. Breast Cancer Res Treat. 2013 Feb;138(1):81-90 - PubMed
  37. Breast Cancer Res. 2007;9(5):R74 - PubMed
  38. J Cell Biochem. 1989 Feb;39(2):167-73 - PubMed
  39. Oncologist. 2013;18(8):917-23 - PubMed
  40. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4218-24 - PubMed
  41. Cancer. 2008 Nov 1;113(9):2422-30 - PubMed
  42. Methods. 2013 Dec 1;64(2):129-36 - PubMed
  43. Cell. 2011 Oct 14;147(2):275-92 - PubMed
  44. Lancet. 2013 Sep 21;382(9897):1021-8 - PubMed
  45. Science. 1989 May 12;244(4905):707-12 - PubMed
  46. Recent Results Cancer Res. 2003;162:149-55 - PubMed
  47. Int J Clin Oncol. 2012 Apr;17(2):96-104 - PubMed
  48. Mol Biotechnol. 2006 Sep;34(1):15-27 - PubMed
  49. Breast Cancer Res Treat. 2011 Jul;128(1):127-36 - PubMed
  50. Cancer Metastasis Rev. 2012 Dec;31(3-4):673-87 - PubMed
  51. Ann Oncol. 2013 May;24(5):1231-8 - PubMed
  52. Breast Cancer Res Treat. 2012 Jul;134(1):283-9 - PubMed
  53. Clin Breast Cancer. 2012 Oct;12(5):340-6 - PubMed
  54. BMC Cancer. 2012 May 16;12:178 - PubMed
  55. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9393-8 - PubMed
  56. Lancet Oncol. 2011 Nov;12(12):1134-42 - PubMed
  57. Lancet Oncol. 2011 Jun;12(6):527-39 - PubMed
  58. Breast Cancer Res Treat. 2011 Jul;128(1):155-63 - PubMed
  59. Ann Oncol. 2012 Mar;23(3):618-624 - PubMed
  60. J Natl Cancer Inst. 2009 Jan 7;101(1):61-6 - PubMed
  61. Chemotherapy. 2012;58(5):364-70 - PubMed
  62. Breast Cancer Res Treat. 2011 May;127(1):33-41 - PubMed
  63. Breast Cancer Res. 2009;11(4):R46 - PubMed
  64. J Clin Oncol. 2012 Feb 20;30(6):587-92 - PubMed
  65. Clin Cancer Res. 2012 Oct 15;18(20):5701-10 - PubMed
  66. Cytotherapy. 2004;6(3):244-52 - PubMed
  67. Ann Oncol. 2008 Mar;19(3):496-500 - PubMed
  68. J Clin Oncol. 2011 Apr 20;29(12):1578-86 - PubMed
  69. Breast Cancer Res Treat. 2010 Nov;124(2):403-12 - PubMed
  70. J Oncol. 2010;2010:426218 - PubMed
  71. Ann Oncol. 2012 May;23(5):1144-1150 - PubMed
  72. J Clin Oncol. 2007 Jan 1;25(1):118-45 - PubMed
  73. Science. 2013 Feb 1;339(6119):580-4 - PubMed
  74. Breast Cancer Res. 2010;12(6):R92 - PubMed
  75. Int J Clin Oncol. 2011 Oct;16(5):596-600 - PubMed
  76. PLoS One. 2010 Sep 08;5(9):e12517 - PubMed
  77. Lab Chip. 2006 Jan;6(1):121-6 - PubMed
  78. Eur J Surg Oncol. 1988 Apr;14(2):111-4 - PubMed
  79. N Engl J Med. 2001 Mar 15;344(11):783-92 - PubMed
  80. Cancer Treat Rev. 2013 Dec;39(8):947-57 - PubMed
  81. PLoS One. 2011 Jan 10;6(1):e15624 - PubMed
  82. N Engl J Med. 2005 Oct 20;353(16):1673-84 - PubMed
  83. N Engl J Med. 2011 Oct 6;365(14):1273-83 - PubMed
  84. Cell. 2006 Nov 17;127(4):679-95 - PubMed
  85. Breast Cancer Res. 2012 May 02;14(3):R70 - PubMed
  86. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18392-7 - PubMed
  87. Clin Cancer Res. 2010 Nov 1;16(21):5233-43 - PubMed
  88. Cancer Treat Rev. 2009 Aug;35(5):463-74 - PubMed

Publication Types