Display options
Cite
Gozashti MH, Gholamhosseinian A, Musavi F, et al. Relationship between serum cystatin C and polycystic ovary syndrome. Iran J Reprod Med. 2013;11(1):71-6
Gozashti, M. H., Gholamhosseinian, A., Musavi, F., & Mashrouteh, M. (2013). Relationship between serum cystatin C and polycystic ovary syndrome. Iranian journal of reproductive medicine, 11(1), 71-6.
Gozashti, Mohammad Hossein, et al. "Relationship between serum cystatin C and polycystic ovary syndrome." Iranian journal of reproductive medicine vol. 11,1 (2013): 71-6.
Gozashti MH, Gholamhosseinian A, Musavi F, Mashrouteh M. Relationship between serum cystatin C and polycystic ovary syndrome. Iran J Reprod Med. 2013 Jan;11(1):71-6. PMID: 24639696; PMCID: PMC3941379.
Copy Download .nbib Format: NLM
Share it on

Iran J Reprod Med. 2013 Jan;11(1):71-6.

Relationship between serum cystatin C and polycystic ovary syndrome.

Iranian journal of reproductive medicine

Mohammad Hossein Gozashti, Ahmad Gholamhosseinian, Fatemeh Musavi, Mahdieh Mashrouteh

Affiliations

  1. Department of Endocrinology, Metabolism and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  2. Department of Biochemistry, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  3. Kerman University of Medical Sciences, Kerman, Iran.

PMID: 24639696 PMCID: PMC3941379

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) causes an increased risk of metabolic cardiovascular syndrome. Also, cystatin C serum levels are associated with the risk of cardiovascular events in metabolic syndrome patients.

OBJECTIVE: To investigate the relationship between cystatin C in PCOS patients.

MATERIALS AND METHODS: 35 women with PCOS were compared to 35 women with healthy matched age and body mass index. They all underwent tests to determine plasma levels of C-reactive protein (CRP), cystatin C, lipid profile and apo-lipoprotein. Blood pressure and demographic variables of each subject were obtained.

RESULTS: Systolic and diastolic blood pressure were higher in PCOS patients compared to control group. Triglyceride and low-density lipoprotein cholesterol levels were higher in PCOS; contrariwise, high-density lipoprotein was lower from that of healthy volunteers. Cystatin and CRP levels were significantly higher in patients with PCOS in comparison with healthy subjects (p<0.0001). Among measured determinants, only PCOS status was independently associated with cystatin C.

CONCLUSION: Cystatin C was positively correlated with PCOS status concentrations but not with systolic and diastolic blood pressure, or any of the lipid profile variables or demographic characteristics. Indeed, no correlation was found between cystatin C and CRP levels. Therefore, cystatin C might be related to PCOS beyond its use as a marker of the renal function.

Keywords: Blood pressure; C-reactive protein; Cystatin C; Dyslipidemia; Polycystic ovary syndrome

References

  1. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1359-66 - PubMed
  2. Clin Biochem. 2006 Jun;39(6):658-61 - PubMed
  3. J Clin Endocrinol Metab. 1998 Sep;83(9):3078-82 - PubMed
  4. Fertil Steril. 2004 Jan;81(1):19-25 - PubMed
  5. Metabolism. 2003 Jul;52(7):908-15 - PubMed
  6. J Am Soc Nephrol. 2006 Jan;17(1):254-61 - PubMed
  7. N Engl J Med. 2005 May 19;352(20):2049-60 - PubMed
  8. J Clin Endocrinol Metab. 2007 Dec;92(12):4609-14 - PubMed
  9. Eur J Obstet Gynecol Reprod Biol. 2005 Jan 10;118(1):4-16 - PubMed
  10. Ann Intern Med. 2005 Apr 5;142(7):497-505 - PubMed
  11. J Am Coll Cardiol. 2006 May 16;47(10):1987-96 - PubMed
  12. Clin Endocrinol (Oxf). 2004 Feb;60(2):241-9 - PubMed
  13. Trends Endocrinol Metab. 2003 Oct;14(8):365-70 - PubMed
  14. Clin Chem. 2002 May;48(5):699-707 - PubMed
  15. J Clin Endocrinol Metab. 1961 Nov;21:1440-7 - PubMed
  16. Circulation. 2007 Jan 16;115(2):173-9 - PubMed
  17. Med Sci Monit. 2008 Feb;14(2):CR97-101 - PubMed
  18. N Engl J Med. 1994 Aug 18;331(7):417-24 - PubMed
  19. Crit Rev Clin Lab Sci. 2004;41(5-6):467-550 - PubMed
  20. J Am Soc Nephrol. 2005 Dec;16(12):3728-35 - PubMed
  21. Am J Med. 2008 May;121(5):426-32 - PubMed
  22. Clin Biochem. 2005 Jan;38(1):1-8 - PubMed
  23. Biol Chem Hoppe Seyler. 1996 Feb;377(2):71-86 - PubMed
  24. Clin Endocrinol (Oxf). 1980 Feb;12(2):177-207 - PubMed
  25. N Engl J Med. 1995 Sep 28;333(13):853-61 - PubMed
  26. Ann Intern Med. 2006 Aug 15;145(4):237-46 - PubMed
  27. Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):797-804 - PubMed
  28. Aust N Z J Obstet Gynaecol. 1989 Nov;29(4):403-16 - PubMed
  29. J Clin Endocrinol Metab. 2005 Apr;90(4):1929-35 - PubMed
  30. Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):263-72 - PubMed

Publication Types