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Tomblin V, Ferguson LR, Han DY, et al. Potential pathway of anti-inflammatory effect by New Zealand honeys. Int J Gen Med. 2014;7:149-58doi: 10.2147/IJGM.S45839.
Tomblin, V., Ferguson, L. R., Han, D. Y., Murray, P., & Schlothauer, R. (2014). Potential pathway of anti-inflammatory effect by New Zealand honeys. International journal of general medicine, 7149-58. https://doi.org/10.2147/IJGM.S45839
Tomblin, Victoria, et al. "Potential pathway of anti-inflammatory effect by New Zealand honeys." International journal of general medicine vol. 7 (2014): 149-58. doi: https://doi.org/10.2147/IJGM.S45839
Tomblin V, Ferguson LR, Han DY, Murray P, Schlothauer R. Potential pathway of anti-inflammatory effect by New Zealand honeys. Int J Gen Med. 2014 Mar 05;7:149-58. doi: 10.2147/IJGM.S45839. eCollection 2014. PMID: 24623989; PMCID: PMC3949697.
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Int J Gen Med. 2014 Mar 05;7:149-58. doi: 10.2147/IJGM.S45839. eCollection 2014.

Potential pathway of anti-inflammatory effect by New Zealand honeys.

International journal of general medicine

Victoria Tomblin, Lynnette R Ferguson, Dug Yeo Han, Pamela Murray, Ralf Schlothauer

Affiliations

  1. Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
  2. Comvita New Zealand Ltd, Paengaroa, New Zealand.

PMID: 24623989 PMCID: PMC3949697 DOI: 10.2147/IJGM.S45839

Abstract

The role of honey in wound healing continues to attract worldwide attention. This study examines the anti-inflammatory effect of four honeys on wound healing, to gauge its efficacy as a treatment option. Isolated phenolics and crude extracts from manuka (Leptospermum scoparium), kanuka (Kunzea ericoides), clover (Trifolium spp.), and a manuka/kanuka blend of honeys were examined. Anti-inflammatory assays were conducted in HEK-Blue™-2, HEK-Blue™-4, and nucleotide oligomerization domain (NOD)2-Wild Type (NOD2-WT) cell lines, to assess the extent to which honey treatment impacts on the inflammatory response and whether the effect was pathway-specific. Kanuka honey, and to a lesser extent manuka honey, produced a powerful anti-inflammatory effect related to their phenolic content. The effect was observed in HEK-Blue™-2 cells using the synthetic tripalmitoylated lipopeptide Pam3CysSerLys4 (Pam3CSK4) ligand, suggesting that honey acts specifically through the toll-like receptor (TLR)1/TLR2 signaling pathway. The manuka/kanuka blend and clover honeys had no significant anti-inflammatory effect in any cell line. The research found that kanuka and manuka honeys have an important role in modulating the inflammatory response associated with wound healing, through a pathway-specific effect. The phenolic content of honey correlates with its effectiveness, although the specific compounds involved remain to be determined.

Keywords: Kunzea ericoides; Leptospermum scoparium; Trifolium; clover; inflammatory response; kanuka; manuka; phenolics; wound healing

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