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Singh N, Goyal M, Malhotra N, et al. Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization. J Hum Reprod Sci. 2013;6(4):245-7doi: 10.4103/0974-1208.126291.
Singh, N., Goyal, M., Malhotra, N., Tiwari, A., & Badiger, S. (2013). Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization. Journal of human reproductive sciences, 6(4), 245-7. https://doi.org/10.4103/0974-1208.126291
Singh, Neeta, et al. "Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization." Journal of human reproductive sciences vol. 6,4 (2013): 245-7. doi: https://doi.org/10.4103/0974-1208.126291
Singh N, Goyal M, Malhotra N, Tiwari A, Badiger S. Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization. J Hum Reprod Sci. 2013 Oct;6(4):245-7. doi: 10.4103/0974-1208.126291. PMID: 24672163; PMCID: PMC3963307.
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J Hum Reprod Sci. 2013 Oct;6(4):245-7. doi: 10.4103/0974-1208.126291.

Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization.

Journal of human reproductive sciences

Neeta Singh, Manu Goyal, Neena Malhotra, Abanish Tiwari, Shreenivas Badiger

Affiliations

  1. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

PMID: 24672163 PMCID: PMC3963307 DOI: 10.4103/0974-1208.126291

Abstract

AIMS: Pregnancies achieved by in vitro fertilization (IVF) are at increased risk of adverse outcome. The main objective of this study was to evaluate the predictive value of β-human chorionic gonadotrophin (β-HCG) and age of the patient for the successful outcome in IVF.

MATERIALS AND METHODS: A retrospective study was done in 139 pregnancies after IVF at single IVF center from June 2007 to July 2012. The age of the patient and initial serum values of β-HCG on day 14 of embryo transfer were correlated with ongoing pregnancy (>12 weeks gestation).

RESULTS: The β-HCG level on day 14 of more than 347 mIU/ml has a sensitivity of 72.2% and specificity of 73.6% in prediction of pregnancy beyond 12 weeks period of gestation. Positive likelihood ratio (LR) is 2.74 and negative LR is 0.37, (receiver operating characteristic area = 0.79).

DISCUSSION: In IVF cycles, there is a lot of stress on the couples while the cycle is going on. There was a positive correlation between the higher values of early serum β-HCG levels and ongoing pregnancy. Hence, it can be used as an independent predictor of a successful outcome of IVF cycle.

CONCLUSION: We concluded from our study that early serum β-HCG can be used as a predictor of a successful outcome in IVF.

Keywords: Age; ongoing pregnancy; prediction; serum marker

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