Display options
Cite
Kukreti V, Shamim M, Khilnani P. Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. Indian J Crit Care Med. 2014;18(2):95-101doi: 10.4103/0972-5229.126079.
Kukreti, V., Shamim, M., & Khilnani, P. (2014). Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 18(2), 95-101. https://doi.org/10.4103/0972-5229.126079
Kukreti, Vinay, et al. "Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy." Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine vol. 18,2 (2014): 95-101. doi: https://doi.org/10.4103/0972-5229.126079
Kukreti V, Shamim M, Khilnani P. Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy. Indian J Crit Care Med. 2014 Feb;18(2):95-101. doi: 10.4103/0972-5229.126079. PMID: 24678152; PMCID: PMC3943134.
Copy Download .nbib Format: NLM
Share it on

Indian J Crit Care Med. 2014 Feb;18(2):95-101. doi: 10.4103/0972-5229.126079.

Intensive care unit acquired weakness in children: Critical illness polyneuropathy and myopathy.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Vinay Kukreti, Mosharraf Shamim, Praveen Khilnani

Affiliations

  1. Departments of Critical Care, Pediatric Critical Care Unit, The Hospital for Sick Children, Toronto, Canada.
  2. Department of Pediatric Critical Care King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  3. Pediatric Critical Care Unit, BLK Superspeciality Hospital, New Delhi.

PMID: 24678152 PMCID: PMC3943134 DOI: 10.4103/0972-5229.126079

Abstract

BACKGROUND AND AIMS: Intensive care unit acquired weakness (ICUAW) is a common occurrence in patients who are critically ill. It is most often due to critical illness polyneuropathy (CIP) or to critical illness myopathy (CIM). ICUAW is increasingly being recognized partly as a consequence of improved survival in patients with severe sepsis and multi-organ failure, partly related to commonly used agents such as steroids and muscle relaxants. There have been occasional reports of CIP and CIM in children, but little is known about their prevalence or clinical impact in the pediatric population. This review summarizes the current understanding of pathophysiology, clinical presentation, diagnosis and treatment of CIP and CIM in general with special reference to published literature in the pediatric age group.

SUBJECTS AND METHODS: Studies were identified through MedLine and Embase using relevant MeSH and Key words. Both adult and pediatric studies were included.

RESULTS: ICUAW in children is a poorly described entity with unknown incidence, etiology and unclear long-term prognosis.

CONCLUSIONS: Critical illness polyneuropathy and myopathy is relatively rare, but clinically significant sequelae of multifactorial origin affecting morbidity, length of intensive care unit (ICU) stay and possibly mortality in critically ill children admitted to pediatric ICU.

Keywords: Children; critical illness myopathy; critical illness polyneuropathy; intensive care unit; intensive care unit acquired weakness; pediatric

References

  1. J Neuroimmunol. 2000 Jul 1;106(1-2):206-13 - PubMed
  2. Intensive Care Med. 2003 Sep;29(9):1505-14 - PubMed
  3. Clin Sci (Lond). 2007 Jul;112(9):499-506 - PubMed
  4. Eur J Anaesthesiol Suppl. 2008;42:181-5 - PubMed
  5. Curr Opin Crit Care. 2010 Apr;16(2):123-7 - PubMed
  6. Muscle Nerve. 1991 Nov;14(11):1103-9 - PubMed
  7. J Child Neurol. 1995 Nov;10(6):486-8 - PubMed
  8. J Clin Invest. 1997 Jan 15;99(2):163-8 - PubMed
  9. Curr Opin Crit Care. 2012 Oct;18(5):509-17 - PubMed
  10. Pediatr Crit Care Med. 2012 Jan;13(1):122; author reply 122-3 - PubMed
  11. Pediatr Crit Care Med. 2012 Mar;13(2):131-5 - PubMed
  12. Crit Care Med. 2007 Feb;35(2):351-7 - PubMed
  13. Neurology. 2003 Dec 23;61(12):1779-82 - PubMed
  14. Intensive Care Med. 1995 Sep;21(9):737-43 - PubMed
  15. Nutrition. 1995 Sep-Oct;11(5):428-32 - PubMed
  16. J Child Neurol. 1995 Sep;10(5):409-11 - PubMed
  17. Am J Respir Crit Care Med. 2007 Mar 1;175(5):480-9 - PubMed
  18. J Physiol. 2011 Aug 1;589(Pt 15):3883-95 - PubMed
  19. Acta Neuropathol. 2003 Jul;106(1):75-82 - PubMed
  20. Muscle Nerve. 2005 Aug;32(2):140-63 - PubMed
  21. Indian J Crit Care Med. 2014 Feb;18(2):95-101 - PubMed
  22. JAMA. 2002 Dec 11;288(22):2859-67 - PubMed
  23. Arch Dis Child. 2002 Feb;86(2):103-7 - PubMed
  24. Curr Opin Crit Care. 2007 Oct;13(5):489-96 - PubMed
  25. Muscle Nerve. 1991 Nov;14(11):1131-9 - PubMed
  26. Brain Dev. 2005 Oct;27(7):535-8 - PubMed
  27. Pediatr Neurol. 1999 Oct;21(4):749-53 - PubMed
  28. J Child Neurol. 2009 Jun;24(6):758-62 - PubMed
  29. Brain. 1987 Aug;110 ( Pt 4):819-41 - PubMed
  30. Can J Anaesth. 2000 Apr;47(4):342-6 - PubMed
  31. Physiol Rev. 2002 Apr;82(2):373-428 - PubMed
  32. J Neurol Sci. 1998 Aug 14;159(2):186-93 - PubMed
  33. Intensive Care Med. 2005 Jan;31(1):157-61 - PubMed
  34. Crit Care Med. 2008 Jun;36(6):1977 - PubMed
  35. J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):838-41 - PubMed
  36. Crit Care Med. 2001 Dec;29(12):2281-6 - PubMed
  37. Chest. 1991 Jan;99(1):176-84 - PubMed
  38. Eur J Anaesthesiol Suppl. 2008;42:66-7 - PubMed
  39. Pediatrics. 1986 Jul;78(1):121-3 - PubMed
  40. Crit Care. 2009;13(1):R5 - PubMed
  41. Nat Rev Neurol. 2009 Jul;5(7):372-9 - PubMed
  42. Crit Care Med. 2006 Nov;34(11):2835-41 - PubMed
  43. Crit Care. 2008;12(6):238 - PubMed
  44. Neuromuscul Disord. 2001 Sep;11(6-7):579-82 - PubMed
  45. Intensive Care Med. 2001 Aug;27(8):1288-96 - PubMed
  46. J Neurol Neurosurg Psychiatry. 1986 May;49(5):563-73 - PubMed
  47. J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1223-31 - PubMed
  48. Curr Opin Crit Care. 2005 Apr;11(2):126-32 - PubMed
  49. J Pediatr. 1995 Feb;126(2):259-61 - PubMed
  50. Crit Care Med. 2009 Oct;37(10 Suppl):S337-46 - PubMed
  51. Neurology. 2005 Apr 26;64(8):1348-53 - PubMed
  52. J Neurol. 2005 Mar;252(3):343-51 - PubMed
  53. Crit Care Med. 2008 May;36(5):1559-63 - PubMed
  54. Eur J Neurol. 2006 Nov;13(11):1203-12 - PubMed
  55. Science. 2007 Jan 12;315(5809):201-5 - PubMed
  56. Muscle Nerve. 2008 Feb;37(2):196-202 - PubMed
  57. Neth J Med. 2000 Jun;56(6):211-4 - PubMed
  58. Intensive Care Med. 1998 Aug;24(8):801-7 - PubMed
  59. Muscle Nerve. 1997 Mar;20(3):316-22 - PubMed
  60. Pediatr Crit Care Med. 2007 Jan;8(1):18-22 - PubMed
  61. J Physiol. 2003 Mar 1;547(Pt 2):555-66 - PubMed
  62. Neuromuscul Disord. 1998 May;8(3-4):186-92 - PubMed
  63. Eur J Paediatr Neurol. 2006 Jul;10(4):176-81 - PubMed

Publication Types