Display options
Cite
Mashayekhi NR, Sadrnia S, Chehrei A, et al. The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity. Int Cardiovasc Res J. 2014;8(1):1-5
Mashayekhi, N. R., Sadrnia, S., Chehrei, A., & Javaheri, J. (2014). The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity. International cardiovascular research journal, 8(1), 1-5.
Mashayekhi, Navid Reza, et al. "The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity." International cardiovascular research journal vol. 8,1 (2014): 1-5.
Mashayekhi NR, Sadrnia S, Chehrei A, Javaheri J. The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity. Int Cardiovasc Res J. 2014 Jan;8(1):1-5. Epub 2014 Jan 01. PMID: 24757643; PMCID: PMC3987460.
Copy Download .nbib Format: NLM
Share it on

Int Cardiovasc Res J. 2014 Jan;8(1):1-5. Epub 2014 Jan 01.

The Correlation between Serum ApoA1 and B and Coronary Artery Disease as Well as Its Severity.

International cardiovascular research journal

Navid Reza Mashayekhi, Saeid Sadrnia, Ali Chehrei, Javad Javaheri

Affiliations

  1. Amirkabir Hospital, Arak University of Medical Sciences, Arak, IR Iran.
  2. Thyroid Research Center, Arak University of Medical Sciences, Arak, IR Iran.
  3. Medical School, Community Medicine Department, Arak University of Medical Sciences, Arak, IR Iran.

PMID: 24757643 PMCID: PMC3987460

Abstract

BACKGROUND: Some patients with Coronary Artery Disease (CAD) have no well-known risk factors of this disease, but are diagnosed with cardiovascular events. The present study aimed to assess the association between Apo A1 and ApoB and the severity of CAD and determine whether these parameters are better predictors of Ischemic Heart Disease (IHD).

METHODS: In this case control study, 271 individuals who were suspicious of having CAD and had been referred to Arak Amir-al-Momenin hospital underwent coronary angiography. Based on the results of angiography, the participants with presence or absence of coronary artery stenosis were allocated into the case and the control group, respectively. The severity of CAD involvement was determined by Gensini score. The data were entered into the SPSS statistical software and analyzed through parametric and non-parametric tests, sensitivity analysis, and logistic regression.

RESULTS: The results revealed no significant correlation between apoA-1 and severity of CAD involvement (GS) (r = 0.017, P = 0.797). However, a significant correlation was found between apoB and GS (r = 0.127, P = 0.047). Logistic regression model showed ApoB, sex, DM and, FH as the only proper predictors of IHD (P < 0.048, P < 0.002, P < 0.040, and P < 0.001, respectively). In comparison to angiography for diagnosis of CAD, ROC analysis represented ApoB as a more useful predictor (P = 0.023).

CONCLUSIONS: In addition to measurement of conventional parameters for assessing CAD high risk groups, according to the results of this study using ApoB would be resonable as well. Further investigations are recommended to clear the problem.

Keywords: Apolipoprotein A-I; Apolipoproteins B; Atherosclerosis; Coronary Artery Disease

References

  1. Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):424-30 - PubMed
  2. Transl Res. 2008 Sep;152(3):113-8 - PubMed
  3. Curr Opin Cardiol. 2007 Jul;22(4):359-67 - PubMed
  4. Acta Paediatr. 2006 Jul;95(7):810-3 - PubMed
  5. Diabetes Obes Metab. 2008 Apr;10(4):271-8 - PubMed
  6. Eur J Clin Invest. 2000 Nov;30(11):947-56 - PubMed
  7. Clin Biochem. 2004 May;37(5):333-43 - PubMed
  8. Clin Biochem. 2008 Feb;41(3):117-20 - PubMed
  9. Saudi Med J. 2009 Mar;30(3):346-52 - PubMed
  10. Circulation. 2005 Nov 29;112(22):3375-83 - PubMed

Publication Types