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J Mol Biochem. 2012;1(1):21-25.

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Journal of molecular biochemistry

Andrea Lossani, Lida Savi, Andrzej Manikowski, Andrew Maioli, Joseph Gambino, Federico Focher, Silvio Spadari, George E Wright

Affiliations

  1. Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy 27100.
  2. GLSynthesis Inc., One Innovation Drive, Worcester, MA 01605.

PMID: 24734222 PMCID: PMC3984574

Abstract

Herpes simplex virus (HSV) types 1 and 2 thymidine kinases (TK) are responsible for phosphorylation of antiherpes acyclonucleosides such as acyclovir (ACV) and 9-(4-hydroxybutyl)guanine (HBG). Related compounds, the N

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