Display options
Cite
Ralevski E, Olivera-Figueroa LA, Petrakis I. PTSD and comorbid AUD: a review of pharmacological and alternative treatment options. Subst Abuse Rehabil. 2014;5:25-36doi: 10.2147/SAR.S37399.
Ralevski, E., Olivera-Figueroa, L. A., & Petrakis, I. (2014). PTSD and comorbid AUD: a review of pharmacological and alternative treatment options. Substance abuse and rehabilitation, 525-36. https://doi.org/10.2147/SAR.S37399
Ralevski, Elizabeth, et al. "PTSD and comorbid AUD: a review of pharmacological and alternative treatment options." Substance abuse and rehabilitation vol. 5 (2014): 25-36. doi: https://doi.org/10.2147/SAR.S37399
Ralevski E, Olivera-Figueroa LA, Petrakis I. PTSD and comorbid AUD: a review of pharmacological and alternative treatment options. Subst Abuse Rehabil. 2014 Mar 07;5:25-36. doi: 10.2147/SAR.S37399. eCollection 2014. PMID: 24648794; PMCID: PMC3953034.
Copy Download .nbib Format: NLM
Share it on

Subst Abuse Rehabil. 2014 Mar 07;5:25-36. doi: 10.2147/SAR.S37399. eCollection 2014.

PTSD and comorbid AUD: a review of pharmacological and alternative treatment options.

Substance abuse and rehabilitation

Elizabeth Ralevski, Lening A Olivera-Figueroa, Ismene Petrakis

Affiliations

  1. Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA.

PMID: 24648794 PMCID: PMC3953034 DOI: 10.2147/SAR.S37399

Abstract

BACKGROUND: Although posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) frequently co-occur there are no specific treatments for individuals diagnosed with these comorbid conditions. The main objectives of this paper are to review the literature on pharmacological options for PTSD and comorbid AUD, and to summarize promising behavioral and alternative interventions for those with these dual diagnoses.

METHODS: We conducted a comprehensive search on PsycINFO and MEDLINE/PubMed databases using Medical Subject Headings terms in various combinations to identify articles that used pharmacotherapy for individuals with dual diagnoses of PTSD and AUD. Similar strategies were used to identify articles on behavioral and alternative treatments for AUD and PTSD. We identified and reviewed six studies that tested pharmacological treatments for patients with PTSD and comorbid AUD.

RESULTS: The literature on treatment with US Food and Drug Administration approved medications for patients with dual diagnosis of PTSD and AUD is very limited and inconclusive. Promising evidence indicates that topiramate and prazosin may be effective in reducing PTSD and AUD symptoms in individuals with comorbidity. Seeking safety has had mixed efficacy in clinical trials. The efficacy of other behavioral and alternative treatments (mindfulness-based, yoga, and acupuncture) is more difficult to evaluate since the evidence comes from small, single studies without comparison groups.

CONCLUSION: There is a clear need for more systematic and rigorous study of pharmacological, behavioral, and alternative treatments for patients with dual diagnoses of PTSD and AUD.

Keywords: AUD; PTSD; dual diagnosis; pharmacotherapy

References

  1. J Clin Psychiatry. 1995 Nov;56(11):502-5 - PubMed
  2. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD002795 - PubMed
  3. Am J Psychiatry. 2003 Feb;160(2):371-3 - PubMed
  4. JAMA. 1986 Sep 19;256(11):1449-55 - PubMed
  5. Compr Psychiatry. 1987 Nov-Dec;28(6):459-66 - PubMed
  6. Evid Based Complement Alternat Med. 2013;2013:615857 - PubMed
  7. J Psychopharmacol. 2008 Jan;22(1):11-23 - PubMed
  8. Behav Cogn Psychother. 2013 May;41(3):290-300 - PubMed
  9. Addict Sci Clin Pract. 2013 Jul 08;8:12 - PubMed
  10. Arch Gen Psychiatry. 1997 Apr;54(4):313-21 - PubMed
  11. J Trauma Stress. 2010 Feb;23(1):59-68 - PubMed
  12. Sci Signal. 2012 Oct 09;5(245):pt6 - PubMed
  13. Evid Based Complement Alternat Med. 2007 Dec;4(4):503-9 - PubMed
  14. Alcohol Alcohol. 2000 Mar-Apr;35(2):202-9 - PubMed
  15. Lancet. 2003 May 17;361(9370):1677-85 - PubMed
  16. J Rehabil Res Dev. 2012;49(5):703-15 - PubMed
  17. Arch Gen Psychiatry. 1995 Dec;52(12):1048-60 - PubMed
  18. Subst Abus. 2009 Oct-Dec;30(4):295-305 - PubMed
  19. Psychiatr Q. 1993 Summer;64(2):151-71 - PubMed
  20. J Clin Psychopharmacol. 2001 Feb;21(1):72-7 - PubMed
  21. Arch Gen Psychiatry. 2010 Jun;67(6):614-23 - PubMed
  22. Neuropsychopharmacology. 2012 Mar;37(4):996-1004 - PubMed
  23. Int Clin Psychopharmacol. 2003 Jan;18(1):1-8 - PubMed
  24. Alcohol Clin Exp Res. 1993 Apr;17(2):211-6 - PubMed
  25. J Clin Psychiatry. 2013 Jun;74(6):e541-50 - PubMed
  26. J Nerv Ment Dis. 1991 Jun;179(6):366-70 - PubMed
  27. J Affect Disord. 2006 Aug;94(1-3):249-53 - PubMed
  28. Am J Psychiatry. 2001 Dec;158(12):1974-81 - PubMed
  29. J Clin Psychopharmacol. 2004 Jun;24(3):291-7 - PubMed
  30. Syst Rev. 2012 Oct 15;1:46 - PubMed
  31. Am J Psychiatry. 1988 Oct;145(10):1289-91 - PubMed
  32. Ugeskr Laeger. 2011 Nov 28;173(48):3103-9 - PubMed
  33. JAMA. 2006 May 3;295(17):2003-17 - PubMed
  34. Depress Anxiety. 2002;15(1):29-33 - PubMed
  35. Depress Anxiety. 2001;13(2):57-71 - PubMed
  36. Alcohol Clin Exp Res. 2005 Mar;29(3):395-401 - PubMed
  37. J Trauma Stress. 2007 Jun;20(3):239-49 - PubMed
  38. Neuropharmacology. 2012 Feb;62(2):552-64 - PubMed
  39. J Clin Psychiatry. 1990 Jun;51(6):236-8 - PubMed
  40. Am J Drug Alcohol Abuse. 2010 Mar;36(2):102-5 - PubMed
  41. Eur Neuropsychopharmacol. 2006 Jul;16(5):340-9 - PubMed
  42. J Subst Abuse Treat. 2003 Sep;25(2):99-105 - PubMed
  43. Biol Psychiatry. 2005 Mar 1;57(5):474-9 - PubMed
  44. Alcohol Alcohol. 2000 Nov-Dec;35(6):587-93 - PubMed
  45. J Clin Psychiatry. 2001;62 Suppl 20:42-8 - PubMed
  46. J Clin Psychopharmacol. 2010 Jun;30(3):318-22 - PubMed
  47. Ann Pharmacother. 2009 Apr;43(4):635-41 - PubMed
  48. J Trauma Stress. 1998 Jul;11(3):437-56 - PubMed
  49. Arch Gen Psychiatry. 2006 Oct;63(10):1158-65 - PubMed
  50. Clin Neuropharmacol. 2010 Sep-Oct;33(5):250-3 - PubMed
  51. Depress Anxiety. 2007;24(2):77-84 - PubMed
  52. Alcohol Clin Exp Res. 2004 Jul;28(7):1051-9 - PubMed
  53. Hum Psychopharmacol. 2004 Oct;19(7):489-94 - PubMed
  54. Int J Neuropsychopharmacol. 2005 Jun;8(2):267-80 - PubMed
  55. CNS Drugs. 2010 Dec;24(12):997-1007 - PubMed
  56. Biol Psychiatry. 2006 Oct 1;60(7):777-83 - PubMed
  57. Addiction. 2013 Feb;108(2):275-93 - PubMed
  58. Alcohol Clin Exp Res. 2008 Jul;32(7):1251-9 - PubMed
  59. Neuropsychopharmacology. 1998 Aug;19(2):123-32 - PubMed
  60. Drug Alcohol Depend. 2004 Jun 11;74(3):223-34 - PubMed
  61. J Clin Psychiatry. 2008 Apr;69(4):533-45 - PubMed
  62. J Subst Abuse Treat. 2010 Jul;39(1):14-21 - PubMed
  63. J Altern Complement Med. 2005 Aug;11(4):711-7 - PubMed
  64. Alcohol Clin Exp Res. 2004 Jan;28(1):51-63 - PubMed
  65. JAMA. 2000 Apr 12;283(14):1837-44 - PubMed
  66. Alcohol Alcohol. 2001 Nov-Dec;36(6):544-52 - PubMed
  67. Am J Drug Alcohol Abuse. 2009;35(2):103-8 - PubMed
  68. J Dual Diagn. 2011 Oct;7(4):285-299 - PubMed
  69. Alcohol Clin Exp Res. 2009 Aug;33(8):1305-13 - PubMed
  70. Behav Modif. 2005 Jan;29(1):10-38 - PubMed
  71. Mayo Clin Proc. 2012 Sep;87(9):890-900 - PubMed
  72. J Consult Clin Psychol. 2009 Aug;77(4):607-19 - PubMed
  73. JAMA. 2007 Nov 14;298(18):2141-8 - PubMed
  74. Psychosomatics. 2010 Nov-Dec;51(6):503-7 - PubMed
  75. J Clin Psychopharmacol. 2002 Dec;22(6):592-8 - PubMed
  76. J Clin Psychopharmacol. 2004 Oct;24(5):532-5 - PubMed
  77. J Trauma Stress. 2013 Apr;26(2):175-83 - PubMed
  78. Addict Behav. 2003 Dec;28(9):1717-30 - PubMed
  79. Acta Psychiatr Scand. 2010 Apr;121(4):289-300 - PubMed
  80. J Psychoactive Drugs. 2005 Dec;37(4):425-35 - PubMed
  81. Asian J Psychiatr. 2009 Mar;2(1):6-16 - PubMed
  82. Psychiatry Res. 2011 Mar 30;186(1):85-90 - PubMed
  83. Alcohol Clin Exp Res. 2009 Feb;33(2):255-63 - PubMed
  84. Mil Med. 2004 Nov;169(11):896-902 - PubMed
  85. J Subst Abuse Treat. 1996 Jan-Feb;13(1):13-22 - PubMed
  86. Arch Gen Psychiatry. 2003 Jan;60(1):92-9 - PubMed
  87. Drug Alcohol Depend. 2013 Oct 1;132(3):630-8 - PubMed
  88. Curr Drug Abuse Rev. 2009 May;2(2):135-42 - PubMed
  89. Addict Behav. 2004 Nov;29(8):1665-72 - PubMed
  90. JAMA. 2011 Aug 3;306(5):493-502 - PubMed
  91. Drug Alcohol Depend. 2010 Apr 1;108(1-2):115-21 - PubMed
  92. Arch Gen Psychiatry. 1992 Nov;49(11):876-80 - PubMed
  93. Am J Drug Alcohol Abuse. 2009;35(5):316-9 - PubMed
  94. J Clin Psychopharmacol. 2006 Jun;26(3):290-302 - PubMed
  95. N Engl J Med. 2001 Dec 13;345(24):1734-9 - PubMed
  96. Addiction. 2007 Jul;102(7):1092-101 - PubMed
  97. J Altern Complement Med. 2005 Feb;11(1):189-201 - PubMed
  98. Brain Res. 2009 Oct 13;1293:24-39 - PubMed
  99. J Clin Psychol. 2012 Jan;68(1):101-16 - PubMed
  100. J Trauma Stress. 2005 Feb;18(1):43-51 - PubMed
  101. J Nerv Ment Dis. 1997 Dec;185(12):761-3 - PubMed
  102. J Trauma Dissociation. 2012;13(1):115-26 - PubMed
  103. Int J Neuropsychopharmacol. 2000 Jun;3(2):135-140 - PubMed
  104. J Trauma Stress. 2004 Apr;17(2):143-7 - PubMed
  105. JAMA. 2008 Aug 13;300(6):663-75 - PubMed
  106. Psychiatr Serv. 2010 Apr;61(4):356-63 - PubMed
  107. J Clin Psychiatry. 2010 May;71(5):634-48 - PubMed
  108. Am J Psychiatry. 2004 Aug;161(8):1426-32 - PubMed
  109. Phys Med Biol. 1997 Feb;42(2):303-11 - PubMed
  110. Acupunct Med. 2007 Jun;25(1-2):1-10 - PubMed
  111. J Clin Psychiatry. 1996 Sep;57(9):390-4 - PubMed
  112. J Clin Psychol. 2012 Jan;68(1):50-66 - PubMed
  113. Am J Psychiatry. 2001 Aug;158(8):1227-30 - PubMed
  114. J Abnorm Psychol. 2011 Nov;120(4):868-77 - PubMed
  115. Addiction. 2008 Dec;103(12):2035-44 - PubMed
  116. J Clin Psychopharmacol. 2005 Apr;25(2):166-9 - PubMed
  117. JAMA. 2005 Apr 6;293(13):1617-25 - PubMed
  118. J Subst Abuse Treat. 2008 Jun;34(4):460-3 - PubMed
  119. Arch Intern Med. 2007 Mar 12;167(5):476-82 - PubMed
  120. Alcohol Clin Exp Res. 2004 Sep;28(9):1356-61 - PubMed
  121. JAMA. 2007 Oct 10;298(14):1641-51 - PubMed
  122. Mil Med. 2009 Aug;174(8):773-8 - PubMed
  123. Addict Biol. 2005 Sep;10(3):289-92 - PubMed
  124. Arch Gen Psychiatry. 2007 Jul;64(7):830-42 - PubMed
  125. Trauma Violence Abuse. 2009 Jul;10(3):290-8 - PubMed
  126. Am J Psychiatry. 2001 Aug;158(8):1184-90 - PubMed
  127. Alcohol Clin Exp Res. 2001 Sep;25(9):1335-41 - PubMed
  128. Actas Esp Psiquiatr. 2010 Jan-Feb;38(1):8-12 - PubMed

Publication Types

Grant support