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Cullen JM, Willson CJ, Minch JD, et al. Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs. J Vet Diagn Invest. 2014;26(3):434-436doi: 10.1177/1040638714532099.
Cullen, J. M., Willson, C. J., Minch, J. D., Kimbrough, C. L., & Mealey, K. L. (2014). Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 26(3), 434-436. https://doi.org/10.1177/1040638714532099
Cullen, John M, et al. "Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs." Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc vol. 26,3 (2014): 434-436. doi: https://doi.org/10.1177/1040638714532099
Cullen JM, Willson CJ, Minch JD, Kimbrough CL, Mealey KL. Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs. J Vet Diagn Invest. 2014 May;26(3):434-436. doi: 10.1177/1040638714532099. Epub 2014 Apr 23. PMID: 24760133.
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J Vet Diagn Invest. 2014 May;26(3):434-436. doi: 10.1177/1040638714532099. Epub 2014 Apr 23.

Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

John M Cullen, Cynthia J Willson, Jonathan D Minch, Carie L Kimbrough, Katrina L Mealey

Affiliations

  1. Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC (Cullen, Willson)Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA (Mealey)GlaxoSmithKline, Research Triangle Park, NC (Kimbrough)Hatfield Marine Science Center, Oregon State University, Newport, OR (Minch).
  2. Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC (Cullen, Willson)Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA (Mealey)GlaxoSmithKline, Research Triangle Park, NC (Kimbrough)Hatfield Marine Science Center, Oregon State University, Newport, OR (Minch) [email protected].

PMID: 24760133 DOI: 10.1177/1040638714532099

Abstract

The etiology of canine gallbladder mucocele (GBM) has not yet been identified. However, several studies have linked GBM in dogs to particular breeds (Shetland Sheepdogs are commonly implicated), concurrent endocrine disease (hyperadrenocorticism and/or hypothyroidism), and a mutation in the canine ABCB4 gene (ABCB4 1583_1584G), particularly in Shetland Sheepdogs. The current study assessed ABCB4 1583_1584G, in a wider sample of dogs with GBM compared with age and breed-matched controls. ABCB4 1583_1584G was identified in 4 of 8 Shetland Sheepdogs and 13 of 28 other breeds with GBM. ABCB4 1583_1584G was also detected in 9 of 12 Shetland Sheepdogs and 23 of 37 other breeds that did not have GBM. No statistically significant association existed between ABCB4 1583_1584G and the presence of GBM for all dogs combined or for Shetland Sheepdogs alone. In contrast to previously reported findings, the current study did not identify a strong association between ABCB4 1583_1584G and GBM in Shetland Sheepdogs or other breeds.

© 2014 The Author(s).

Keywords: ABCB4 gene; canine; gall bladder; mucocele

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