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Bottone MG, Santin G, Aredia F, et al. Morphological Features of Organelles during Apoptosis: An Overview. Cells. 2013;2(2):294-305doi: 10.3390/cells2020294.
Bottone, M. G., Santin, G., Aredia, F., Bernocchi, G., Pellicciari, C., & Scovassi, A. I. (2013). Morphological Features of Organelles during Apoptosis: An Overview. Cells, 2(2), 294-305. https://doi.org/10.3390/cells2020294
Bottone, Maria Grazia, et al. "Morphological Features of Organelles during Apoptosis: An Overview." Cells vol. 2,2 (2013): 294-305. doi: https://doi.org/10.3390/cells2020294
Bottone MG, Santin G, Aredia F, Bernocchi G, Pellicciari C, Scovassi AI. Morphological Features of Organelles during Apoptosis: An Overview. Cells. 2013 May 08;2(2):294-305. doi: 10.3390/cells2020294. PMID: 24709702; PMCID: PMC3972681.
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Cells. 2013 May 08;2(2):294-305. doi: 10.3390/cells2020294.

Morphological Features of Organelles during Apoptosis: An Overview.

Cells

Maria Grazia Bottone, Giada Santin, Francesca Aredia, Graziella Bernocchi, Carlo Pellicciari, Anna Ivana Scovassi

Affiliations

  1. Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. [email protected].
  2. Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy. [email protected].
  3. Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. [email protected].
  4. Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia e Biotecnologie "L. Spallanzani", Università di Pavia, 27100 Pavia, Italy. [email protected].
  5. Istituto di Genetica Molecolare CNR, 27100 Pavia, Italy. [email protected].

PMID: 24709702 PMCID: PMC3972681 DOI: 10.3390/cells2020294

Abstract

An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.

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