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Aburto MR, Hurlé JM, Varela-Nieto I, et al. Autophagy during vertebrate development. Cells. 2012;1(3):428-48doi: 10.3390/cells1030428.
Aburto, M. R., Hurlé, J. M., Varela-Nieto, I., & Magariños, M. (2012). Autophagy during vertebrate development. Cells, 1(3), 428-48. https://doi.org/10.3390/cells1030428
Aburto, María R, et al. "Autophagy during vertebrate development." Cells vol. 1,3 (2012): 428-48. doi: https://doi.org/10.3390/cells1030428
Aburto MR, Hurlé JM, Varela-Nieto I, Magariños M. Autophagy during vertebrate development. Cells. 2012 Aug 02;1(3):428-48. doi: 10.3390/cells1030428. PMID: 24710484; PMCID: PMC3901104.
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Cells. 2012 Aug 02;1(3):428-48. doi: 10.3390/cells1030428.

Autophagy during vertebrate development.

Cells

María R Aburto, Juan M Hurlé, Isabel Varela-Nieto, Marta Magariños

Affiliations

  1. Institute for Biomedical Research "Alberto Sols", CSIC-UAM, C/ Arturo Duperier 4, Madrid 28029, Spain. [email protected].
  2. Departamentos de Anatomía y Biología Celular, Universidad de Cantabria, Santander 39011, Spain. [email protected].
  3. Institute for Biomedical Research "Alberto Sols", CSIC-UAM, C/ Arturo Duperier 4, Madrid 28029, Spain. [email protected].
  4. Institute for Biomedical Research "Alberto Sols", CSIC-UAM, C/ Arturo Duperier 4, Madrid 28029, Spain. [email protected].

PMID: 24710484 PMCID: PMC3901104 DOI: 10.3390/cells1030428

Abstract

Autophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.

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