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de Blank P, Cole K, Kersun L, et al. fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies. Curr Oncol. 2014;21(2):e345-8doi: 10.3747/co.21.1803.
de Blank, P., Cole, K., Kersun, L., Green, A., Wilkes, J. J., Belasco, J., Bagatell, R., Bailey, L. C., & Fisher, M. J. (2014). fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies. Current oncology (Toronto, Ont.), 21(2), e345-8. https://doi.org/10.3747/co.21.1803
de Blank, P, et al. "fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies." Current oncology (Toronto, Ont.) vol. 21,2 (2014): e345-8. doi: https://doi.org/10.3747/co.21.1803
de Blank P, Cole K, Kersun L, Green A, Wilkes JJ, Belasco J, Bagatell R, Bailey LC, Fisher MJ. fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies. Curr Oncol. 2014 Apr;21(2):e345-8. doi: 10.3747/co.21.1803. PMID: 24764718; PMCID: PMC3997466.
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Curr Oncol. 2014 Apr;21(2):e345-8. doi: 10.3747/co.21.1803.

fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies.

Current oncology (Toronto, Ont.)

P de Blank, K Cole, L Kersun, A Green, J J Wilkes, J Belasco, R Bagatell, L C Bailey, M J Fisher

Affiliations

  1. Department of Pediatrics, Division of Pediatric Hematology and Oncology, Rainbow Babies and Children's Hospital, Cleveland, OH, U.S.A.
  2. Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A. ; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, U.S.A.

PMID: 24764718 PMCID: PMC3997466 DOI: 10.3747/co.21.1803

Abstract

Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although (18)F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours.

Keywords: Hodgkin lymphoma; Klinefelter syndrome; Neurofibromatosis type 1; germ-cell tumours; pediatric oncology

References

  1. Pediatrics. 2008 Mar;121(3):633-42 - PubMed
  2. Eur J Nucl Med Mol Imaging. 2009 May;36(5):751-7 - PubMed
  3. J Clin Oncol. 2006 Jun 1;24(16):2570-5 - PubMed
  4. Br J Cancer. 2006 Jul 17;95(2):233-8 - PubMed
  5. Skeletal Radiol. 2013 Sep;42(9):1317-22 - PubMed
  6. Radiol Res Pract. 2012;2012:431029 - PubMed
  7. Eur J Surg Oncol. 2003 Aug;29(6):536-41 - PubMed
  8. J Neurooncol. 2008 Apr;87(2):165-71 - PubMed
  9. J Pediatr. 2004 May;144(5):666-8 - PubMed
  10. PET Clin. 2008 Oct;3(4):531-49 - PubMed
  11. Cancer. 1993 Nov 1;72(9):2746-54 - PubMed
  12. Neuron. 2002 Mar 14;33(6):845-8 - PubMed
  13. Eur J Nucl Med Mol Imaging. 2010 Jul;37(7):1309-17 - PubMed
  14. Br J Cancer. 1994 Nov;70(5):969-72 - PubMed
  15. Med Pediatr Oncol. 1988;16(2):116-7 - PubMed
  16. Cell. 1992 Apr 17;69(2):275-81 - PubMed
  17. Arch Dermatol. 2005 Jan;141(1):71-4 - PubMed
  18. Oncologist. 2012;17(1):101-16 - PubMed
  19. Ann Oncol. 2008 Feb;19(2):390-4 - PubMed
  20. J Neurol Neurosurg Psychiatry. 2000 Mar;68(3):353-7 - PubMed
  21. J Trop Pediatr. 2010 Feb;56(1):69-72 - PubMed
  22. AJR Am J Roentgenol. 2007 Oct;189(4):928-35 - PubMed
  23. Int J Dermatol. 2009 Oct;48(10):1105-9 - PubMed
  24. Br J Cancer. 1995 Feb;71(2):416-20 - PubMed
  25. Cancer. 1990 Jan 1;65(1):45-52 - PubMed
  26. J Urol. 1999 Nov;162(5):1582-6 - PubMed

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