Display options
Cite
Wolff RF, Reid K, di Nisio M, et al. Systematic review of adverse events of buprenorphine patch versus fentanyl patch in patients with chronic moderate-to-severe pain. Pain Manag. 2012;2(4):351-62doi: 10.2217/pmt.12.22.
Wolff, R. F., Reid, K., di Nisio, M., Aune, D., Truyers, C., Hernandez, A. V., Misso, K., Riemsma, R., & Kleijnen, J. (2012). Systematic review of adverse events of buprenorphine patch versus fentanyl patch in patients with chronic moderate-to-severe pain. Pain management, 2(4), 351-62. https://doi.org/10.2217/pmt.12.22
Wolff, Robert F, et al. "Systematic review of adverse events of buprenorphine patch versus fentanyl patch in patients with chronic moderate-to-severe pain." Pain management vol. 2,4 (2012): 351-62. doi: https://doi.org/10.2217/pmt.12.22
Wolff RF, Reid K, di Nisio M, Aune D, Truyers C, Hernandez AV, Misso K, Riemsma R, Kleijnen J. Systematic review of adverse events of buprenorphine patch versus fentanyl patch in patients with chronic moderate-to-severe pain. Pain Manag. 2012 Jul;2(4):351-62. doi: 10.2217/pmt.12.22. PMID: 24654721.
Copy Download .nbib Format: NLM
Share it on

Pain Manag. 2012 Jul;2(4):351-62. doi: 10.2217/pmt.12.22.

Systematic review of adverse events of buprenorphine patch versus fentanyl patch in patients with chronic moderate-to-severe pain.

Pain management

Robert F Wolff, Kim Reid, Marcello di Nisio, Dagfinn Aune, Carla Truyers, Adrian V Hernandez, Kate Misso, Rob Riemsma, Jos Kleijnen

Affiliations

  1. Kleijnen Systematic Reviews Ltd, Unit 6, Escrick Business Park, Riccall Road, Escrick, York, YO19 6FD, UK.

PMID: 24654721 DOI: 10.2217/pmt.12.22

Abstract

SUMMARY This systematic review compares convenience of administration, adverse events and tolerability of buprenorphine patch with fentanyl patch in patients with chronic pain. Methods of quantitative and qualitative research were combined. Seventeen databases were searched up to December 2010. A total of 49 unique trials (56 publications) were included. Patients regarded the use of patches, both transdermal buprenorphine and fentanyl, as easy and convenient. Compared with buprenorphine patch, fentanyl can cause more cases of constipation and could lead to a higher number of serious adverse events. There were no differences between buprenorphine patch and fentanyl patch regarding dizziness, somnolence, nausea and treatment discontinuation. Overall, transdermal administration of buprenorphine and fentanyl can be seen as an alternative pathway for delivering these drugs. Use of transdermal buprenorphine might be favorable in certain groups of patients, such as renally impaired, elderly and immunosuppressed patients.

Publication Types