Display options
Cite
Kinoshita H, Ishii A, Hayakawa A, et al. Severe hypothyroidism associated with the degree of edema in a patient with nephrosis. Clin Pract. 2011;1(3):e78doi: 10.4081/cp.2011.e78.
Kinoshita, H., Ishii, A., Hayakawa, A., Yasuda, M., Inoshita, S., & Yakushiji, F. (2011). Severe hypothyroidism associated with the degree of edema in a patient with nephrosis. Clinics and practice, 1(3), e78. https://doi.org/10.4081/cp.2011.e78
Kinoshita, Hiroyuki, et al. "Severe hypothyroidism associated with the degree of edema in a patient with nephrosis." Clinics and practice vol. 1,3 (2011): e78. doi: https://doi.org/10.4081/cp.2011.e78
Kinoshita H, Ishii A, Hayakawa A, Yasuda M, Inoshita S, Yakushiji F. Severe hypothyroidism associated with the degree of edema in a patient with nephrosis. Clin Pract. 2011 Oct 13;1(3):e78. doi: 10.4081/cp.2011.e78. eCollection 2011 Jul 01. PMID: 24765339; PMCID: PMC3981359.
Copy Download .nbib Format: NLM
Share it on

Clin Pract. 2011 Oct 13;1(3):e78. doi: 10.4081/cp.2011.e78. eCollection 2011 Jul 01.

Severe hypothyroidism associated with the degree of edema in a patient with nephrosis.

Clinics and practice

Hiroyuki Kinoshita, Amiko Ishii, Akiko Hayakawa, Mutsuko Yasuda, Seiji Inoshita, Fumiatsu Yakushiji

Affiliations

  1. Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.

PMID: 24765339 PMCID: PMC3981359 DOI: 10.4081/cp.2011.e78

Abstract

We report the pleural fluid values of thyroid hormones and their carrier proteins in a patient who suffered from nephrotic syndrome with renal insufficiency and transient hypothyroidism. The pleural effusion was transudate. The concentrations of thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (Alb) were approximately 30-50% of the plasma. The concentrations of total triiodothyronine (TT3), total tetraiodothyronine (TT4), free triiodothyronine (FT3), and free tetraiodothyronine (FT4) were approximately 30-50% of the plasma. Hypothyroidism was associated with the degree of edema. After improving systemic edema, proteinuria remained unchanged but the patient did not require levothyroxine. We speculate that the large amount of transudation of thyroid hormones with their carrier proteins from the blood vessels to the third space (edema and pleural effusion), thereby reducing thyroid hormones in the plasma, was associated with hypothyroidism.

Keywords: edema; hypothyroidism; nephrotic syndrome.; pleural effusion; thyroid hormone-binding proteins; thyroid hormones

References

  1. J Clin Endocrinol Metab. 1976 Mar;42(3):504-13 - PubMed
  2. J Postgrad Med. 2006 Jul-Sep;52(3):201-3 - PubMed
  3. J Clin Endocrinol Metab. 1976 Mar;42(3):494-503 - PubMed
  4. Endocr Res. 2010;35(4):183-7 - PubMed
  5. Neth J Med. 2009 Apr;67(4):153 - PubMed

Publication Types