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Zaretsky DV, Zaretskaia MV, Durant PJ, et al. Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment. Pharmacol Res Perspect. 2014;2(2):e00031doi: 10.1002/prp2.31.
Zaretsky, D. V., Zaretskaia, M. V., Durant, P. J., & Rusyniak, D. E. (2014). Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment. Pharmacology research & perspectives, 2(2), e00031. https://doi.org/10.1002/prp2.31
Zaretsky, Dmitry V, et al. "Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment." Pharmacology research & perspectives vol. 2,2 (2014): e00031. doi: https://doi.org/10.1002/prp2.31
Zaretsky DV, Zaretskaia MV, Durant PJ, Rusyniak DE. Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment. Pharmacol Res Perspect. 2014 Apr 01;2(2):e00031. doi: 10.1002/prp2.31. PMID: 24765530; PMCID: PMC3994179.
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Pharmacol Res Perspect. 2014 Apr 01;2(2):e00031. doi: 10.1002/prp2.31.

Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment.

Pharmacology research & perspectives

Dmitry V Zaretsky, Maria V Zaretskaia, Pamela J Durant, Daniel E Rusyniak

Affiliations

  1. Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  2. Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

PMID: 24765530 PMCID: PMC3994179 DOI: 10.1002/prp2.31

Abstract

The central mechanisms through which MDMA mediates life-threatening hyperthermia when taken in a warm environment are not well described. It is assumed that MDMA alters normal thermoregulatory circuits resulting in increased heat production through interscapular brown adipose tissue (iBAT) and decreased heat dissipation through cutaneous vasoconstriction. We studied the role of the dorsomedial hypothalamus (DMH) and medullary raphe pallidus (mRPa) in mediating iBAT, tail blood flow, and locomotor effects produced by MDMA. Rats were instrumented with guide cannulas targeting either the DMH or the mRPa-brain regions involved in regulating iBAT and cutaneous vascular beds. In all animals, core temperature and locomotion were recorded with surgically implanted telemetric transmitters; and additionally either iBAT temperature (via telemetric transmitter) or tail artery blood flow (via tail artery Doppler cuff) were also recorded. Animals were placed in an environmental chamber at 32°C and microinjected with either control or the GABA agonist muscimol (80pmol) followed by an intravenous injection of saline or MDMA (7.5 mg kg

Keywords: MDMA; ambient temperature; cutaneous blood flow; dorsomedial hypothalamus; hyperthermia; interscapular brown adipose tissue; locomotion; medullary raphe pallidus; thermoregulation

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