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Davis PR, Head E. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol. 2014;5:47doi: 10.3389/fphar.2014.00047.
Davis, P. R., & Head, E. (2014). Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Frontiers in pharmacology, 547. https://doi.org/10.3389/fphar.2014.00047
Davis, Paulina R, and Head, Elizabeth. "Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges." Frontiers in pharmacology vol. 5 (2014): 47. doi: https://doi.org/10.3389/fphar.2014.00047
Davis PR, Head E. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol. 2014 Mar 21;5:47. doi: 10.3389/fphar.2014.00047. eCollection 2014. PMID: 24711794; PMCID: PMC3968758.
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Front Pharmacol. 2014 Mar 21;5:47. doi: 10.3389/fphar.2014.00047. eCollection 2014.

Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges.

Frontiers in pharmacology

Paulina R Davis, Elizabeth Head

Affiliations

  1. Sanders-Brown Center on Aging, University of Kentucky Lexington, KY, USA ; Department of Molecular and Biomedical Pharmacology, University of Kentucky Lexington, KY, USA.

PMID: 24711794 PMCID: PMC3968758 DOI: 10.3389/fphar.2014.00047

Abstract

Aged dogs spontaneously develop many features of human aging and Alzheimer's disease (AD) including cognitive decline and neuropathology. In this review, we discuss age-dependent learning tasks, memory tasks, and functional measures that can be used in aged dogs for sensitive treatment outcome measures. Neuropathology that is linked to cognitive decline is described along with examples of treatment studies that show reduced neuropathology in aging dogs (dietary manipulations, behavioral enrichment, immunotherapy, and statins). Studies in canine show that multi-targeted approaches may be more beneficial than single pathway manipulations (e.g., antioxidants combined with behavioral enrichment). Aging canine studies show good predictive validity for human clinical trials outcomes (e.g., immunotherapy) and several interventions tested in dogs strongly support a prevention approach (e.g., immunotherapy and statins). Further, dogs are ideally suited for prevention studies as they the age because onset of cognitive decline and neuropathology strongly support longitudinal interventions that can be completed within a 3-5 year period. Disadvantages to using the canine model are that they lengthy, use labor-intensive comprehensive cognitive testing, and involve costly housing (almost as high as that of non-human primates). However, overall, using the dog as a preclinical model for testing preventive approaches for AD may complement work in rodents and non-human primates.

Keywords: antioxidant diet; atorvastatin; behavioral enrichment; beta-amyloid; combination treatment; dog; immunotherapy; statin

References

  1. Brain Res. 1997 Nov 7;774(1-2):35-43 - PubMed
  2. Curr Alzheimer Res. 2012 Mar;9(3):298-314 - PubMed
  3. Neurobiol Learn Mem. 2007 Sep;88(2):249-59 - PubMed
  4. J Comp Neurol. 1997 Mar 24;379(4):482-94 - PubMed
  5. Neurology. 2005 May 10;64(9):1553-62 - PubMed
  6. Neuropsychology. 1998 Jan;12(1):95-114 - PubMed
  7. Neurobiol Aging. 2000 Sep-Oct;21(5):695-704 - PubMed
  8. J Neuropathol Exp Neurol. 1997 Apr;56(4):414-20 - PubMed
  9. Vet Clin North Am Small Anim Pract. 1997 Nov;27(6):1537-59 - PubMed
  10. Free Radic Biol Med. 2007 Sep 1;43(5):658-77 - PubMed
  11. Arch Neurol. 2005 May;62(5):753-7 - PubMed
  12. Neurobiol Aging. 2005 Jan;26(1):77-90 - PubMed
  13. Psychol Bull. 1968 Dec;70(6):782-93 - PubMed
  14. Arch Neurol. 2002 Feb;59(2):223-7 - PubMed
  15. J Neurosci. 2004 Sep 22;24(38):8205-13 - PubMed
  16. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22 - PubMed
  17. Nature. 1999 Jul 8;400(6740):173-7 - PubMed
  18. J Mol Neurosci. 2002 Aug-Oct;19(1-2):155-61 - PubMed
  19. J Neurochem. 2012 Jan;120(1):135-46 - PubMed
  20. J Comp Psychol. 2007 Aug;121(3):270-81 - PubMed
  21. J Neurosci Res. 2004 Sep 15;77(6):913-20 - PubMed
  22. Acta Neuropathol. 2005 Sep;110(3):222-31 - PubMed
  23. Ann Neurol. 2002 Sep;52(3):346-50 - PubMed
  24. Neuroreport. 1996 Jan 31;7(2):562-4 - PubMed
  25. Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S91-4 - PubMed
  26. Acta Neuropathol. 1991;82(4):239-59 - PubMed
  27. Curr Alzheimer Res. 2005 Jul;2(3):343-53 - PubMed
  28. Neurosci Biobehav Rev. 2002 Oct;26(6):679-95 - PubMed
  29. Pharmacol Biochem Behav. 1992 Nov;43(3):749-57 - PubMed
  30. Neuroscience. 2000;96(3):495-506 - PubMed
  31. J Alzheimers Dis. 2006;9(3 Suppl):151-3 - PubMed
  32. J Gerontol A Biol Sci Med Sci. 2002 Jul;57(7):M414-8 - PubMed
  33. Brain Cogn. 1989 Sep;11(1):114-26 - PubMed
  34. Biochem J. 1996 Jan 15;313 ( Pt 2):575-80 - PubMed
  35. J Am Geriatr Soc. 2002 Nov;50(11):1852-6 - PubMed
  36. Neurobiol Aging. 1993 Jul-Aug;14(4):287-93 - PubMed
  37. J Alzheimers Dis. 2012;32(4):1029-42 - PubMed
  38. Neurobiol Aging. 2002 Sep-Oct;23(5):809-18 - PubMed
  39. BMC Med. 2007 Jul 19;5:20 - PubMed
  40. Brain Res. 2007 Mar 30;1139:85-94 - PubMed
  41. Dev Psychobiol. 1970;2(4):277-80 - PubMed
  42. Neurobiol Aging. 1998 Sep-Oct;19(5):479-85 - PubMed
  43. Trends Neurosci. 2001 Nov;24(11 Suppl):S45-8 - PubMed
  44. Lancet. 2000 Nov 11;356(9242):1627-31 - PubMed
  45. Pharmacol Res. 2011 Mar;63(3):172-80 - PubMed
  46. J Neurosci. 2010 Jul 21;30(29):9831-9 - PubMed
  47. Neuroreport. 1992 Dec;3(12):1093-6 - PubMed
  48. Science. 1987 Feb 20;235(4791):873-7 - PubMed
  49. Trends Mol Med. 2001 Dec;7(12):548-54 - PubMed
  50. Amyloid. 2001 Mar;8(1):11-21 - PubMed
  51. Neuroepidemiology. 2004 Jan-Apr;23(1-2):94-8 - PubMed
  52. J Alzheimers Dis. 2010;22(1):135-50 - PubMed
  53. Behav Brain Res. 2008 Sep 1;192(1):106-13 - PubMed
  54. Neurobiol Aging. 2012 Mar;33(3):546-54 - PubMed
  55. J Vet Med Sci. 2005 Oct;67(10):961-7 - PubMed
  56. Neurobiol Aging. 2013 Sep;34(9):2125-32 - PubMed
  57. Science. 1992 Apr 10;256(5054):184-5 - PubMed
  58. J Alzheimers Dis. 2010;20(2):637-46 - PubMed
  59. Behav Neurosci. 1994 Feb;108(1):57-68 - PubMed
  60. Neuroreport. 1994 Sep 8;5(14):1825-8 - PubMed
  61. Learn Mem. 2001 Nov-Dec;8(6):317-25 - PubMed
  62. Lab Invest. 1970 Sep;23(3):287-96 - PubMed
  63. Neurobiol Aging. 2005 May;26(5):749-63 - PubMed
  64. Neurobiol Aging. 2008 Jan;29(1):39-50 - PubMed
  65. Chem Res Toxicol. 1997 May;10(5):495-506 - PubMed
  66. Neuropsychologia. 2003;41(2):229-34 - PubMed
  67. Arch Neurol. 2002 Jun;59(6):972-6 - PubMed
  68. Nat Med. 2003 Apr;9(4):448-52 - PubMed
  69. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10540-3 - PubMed
  70. J Vet Med Sci. 2008 Mar;70(3):273-7 - PubMed
  71. Vet Clin North Am Small Anim Pract. 2012 Jul;42(4):749-68, vii - PubMed
  72. Neurobiol Aging. 2002 Sep-Oct;23(5):737-45 - PubMed
  73. J Comp Neurol. 2009 Apr 1;513(4):417-29 - PubMed
  74. Behav Neurosci. 2002 Jun;116(3):443-54 - PubMed
  75. Vet Ther. 2001 Summer;2(3):247-60 - PubMed
  76. Neurobiol Aging. 1998 Sep-Oct;19(5):415-25 - PubMed
  77. J Alzheimers Dis. 2008 Dec;15(4):685-707 - PubMed
  78. Biochim Biophys Acta. 2000 Jul 26;1502(1):139-44 - PubMed
  79. Neurology. 1996 Jun;46(6):1592-6 - PubMed
  80. Nature. 2013 Mar 21;495(7441):360-4 - PubMed
  81. Behav Brain Res. 2004 Aug 12;153(1):199-210 - PubMed
  82. J Neural Transm (Vienna). 2006 Nov;113(11):1625-44 - PubMed
  83. Acta Neuropathol. 2005 Oct;110(4):345-59 - PubMed
  84. Arch Neurol. 2001 Sep;58(9):1395-402 - PubMed
  85. J Neurochem. 2002 Jul;82(2):375-81 - PubMed
  86. Behav Neurosci. 1995 Oct;109(5):851-8 - PubMed
  87. Int J Neuropsychopharmacol. 2012 Aug;15(7):981-7 - PubMed
  88. Neuropsychopharmacology. 1998 Jun;18(6):407-30 - PubMed
  89. Arch Neurol. 2000 Oct;57(10):1439-43 - PubMed
  90. Hippocampus. 1995;5(4):363-70 - PubMed
  91. Neurobiol Dis. 2008 Feb;29(2):169-75 - PubMed
  92. Acta Neuropathol. 2006 Jun;111(6):519-28 - PubMed
  93. Biochem Pharmacol. 2014 Apr 15;88(4):508-16 - PubMed
  94. Cardiology. 1990;77 Suppl 4:14-21 - PubMed
  95. Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006395 - PubMed
  96. Nihon Juigaku Zasshi. 1990 Jun;52(3):605-11 - PubMed
  97. Exp Gerontol. 2004 May;39(5):753-65 - PubMed
  98. Neurobiol Aging. 2004 May-Jun;25(5):589-97; discussion 603-4 - PubMed
  99. Neurosci Lett. 1990 Jul 3;114(2):178-83 - PubMed
  100. Neurology. 2005 May 10;64(9):1531-8 - PubMed
  101. Curr Neuropharmacol. 2011 Dec;9(4):651-61 - PubMed
  102. Am J Med. 1989 Oct 16;87(4A):28S-38S - PubMed
  103. Curr Alzheimer Res. 2005 Jul;2(3):307-18 - PubMed
  104. J Pharmacol Exp Ther. 2006 Mar;316(3):1146-52 - PubMed
  105. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):41-8 - PubMed
  106. Neurobiol Learn Mem. 1996 Jul;66(1):11-23 - PubMed
  107. Neurobiol Aging. 2012 Jan;33(1):108-20 - PubMed
  108. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4 - PubMed
  109. Neurobiol Aging. 1996 Mar-Apr;17(2):259-68 - PubMed
  110. Br J Nutr. 2010 Jun;103(12):1746-54 - PubMed
  111. Neurobiol Aging. 2005 Apr;26(4):553-9 - PubMed
  112. Neurosci Lett. 2008 Mar 21;434(1):99-103 - PubMed
  113. Exp Neurol. 2009 Nov;220(1):171-6 - PubMed
  114. Neurobiol Aging. 1993 Nov-Dec;14(6):547-60 - PubMed
  115. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):389-97 - PubMed
  116. Learn Mem. 2003 Jan-Feb;10(1):64-73 - PubMed
  117. Curr Alzheimer Res. 2007 Apr;4(2):191-7 - PubMed
  118. Neurology. 1996 Mar;46(3):707-19 - PubMed
  119. Learn Mem. 1999 Jan-Feb;6(1):54-61 - PubMed
  120. Acta Neurol Scand Suppl. 2006;185:78-86 - PubMed
  121. Amyloid. 2004 Jun;11(2):90-100 - PubMed
  122. Brain Pathol. 2006 Jan;16(1):40-54 - PubMed
  123. Science. 2003 Apr 18;300(5618):486-9 - PubMed
  124. Science. 2004 May 21;304(5674):1160-4 - PubMed
  125. Neurology. 1984 Jul;34(7):939-44 - PubMed
  126. Neurosci Lett. 2011 Aug 26;501(2):92-5 - PubMed
  127. Biochem Pharmacol. 2013 Feb 1;85(3):289-305 - PubMed
  128. Brain Res Mol Brain Res. 1991 Jul;10(4):299-305 - PubMed
  129. Behav Neurosci. 1990 Dec;104(6):876-84 - PubMed
  130. Biochim Biophys Acta. 2013 Sep;1832(9):1384-9 - PubMed
  131. Neurobiol Aging. 2008 Jan;29(1):51-70 - PubMed
  132. Nat Med. 1998 Nov;4(11):1313-7 - PubMed
  133. Neurobiol Learn Mem. 2006 Sep;86(2):197-204 - PubMed
  134. J Nucl Med. 1993 Oct;34(10):1681-7 - PubMed
  135. Neurobiol Aging. 2010 Apr;31(4):625-35 - PubMed
  136. Neurobiol Dis. 2009 Sep;35(3):352-8 - PubMed
  137. Brain Res Brain Res Rev. 2003 Oct;43(2):207-23 - PubMed
  138. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1393-404 - PubMed
  139. Acta Neurol Scand Suppl. 2006;185:3-7 - PubMed
  140. Neurobiol Aging. 2000 Jan-Feb;21(1):89-96 - PubMed
  141. Annu Rev Psychol. 1997;48:339-70 - PubMed
  142. Exp Gerontol. 2003 Jun;38(6):711-9 - PubMed
  143. J Neurosci. 2008 Apr 2;28(14):3555-66 - PubMed
  144. Lancet. 1994 Sep 17;344(8925):769-72 - PubMed
  145. Neurology. 2005 Jan 11;64(1):129-31 - PubMed
  146. J Vet Med Sci. 1992 Aug;54(4):659-67 - PubMed
  147. Brain Res. 1998 Aug 17;802(1-2):259-66 - PubMed
  148. Neurobiol Aging. 1995 Nov-Dec;16(6):947-54 - PubMed
  149. Drugs. 1990 Oct;40(4):583-607 - PubMed
  150. Free Radic Biol Med. 2002 Sep 1;33(5):620-6 - PubMed
  151. Biochem Soc Trans. 2002 Aug;30(4):552-7 - PubMed
  152. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):801-10 - PubMed
  153. Science. 1985 Dec 13;230(4731):1273-6 - PubMed
  154. Behav Genet. 2003 Mar;33(2):181-9 - PubMed
  155. Curr Alzheimer Res. 2013 Jun;10(5):482-93 - PubMed
  156. Neurobiol Aging. 1988 Sep-Dec;9(5-6):657-66 - PubMed
  157. Arch Neurol. 2006 Jan;63(1):38-46 - PubMed
  158. Ann Anat. 2001 May;183(3):283-91 - PubMed
  159. Physiol Behav. 1997 Nov;62(5):963-71 - PubMed
  160. Exp Neurol. 2000 May;163(1):111-22 - PubMed
  161. Brain Res. 2006 Jan 19;1069(1):216-26 - PubMed
  162. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):361-9 - PubMed
  163. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):461-9 - PubMed
  164. J Neurochem. 1999 Feb;72(2):771-6 - PubMed
  165. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):675-92 - PubMed
  166. J Comp Physiol Psychol. 1973 Feb;82(2):227-39 - PubMed
  167. Brain Pathol. 2004 Jan;14(1):11-20 - PubMed
  168. Pharmacol Biochem Behav. 2000 Jun;66(2):293-300 - PubMed
  169. Acta Neuropathol. 2006 Aug;112(2):175-83 - PubMed
  170. Lancet. 2008 Jul 19;372(9634):216-23 - PubMed
  171. Mol Neurobiol. 2008 Feb;37(1):73-82 - PubMed
  172. Vet Clin North Am Small Anim Pract. 2005 May;35(3):675-98 - PubMed
  173. Neurology. 2002 Jun 25;58(12):1791-800 - PubMed
  174. Ann N Y Acad Sci. 2000 Jun;908:255-9 - PubMed
  175. J Vet Med Sci. 1991 Dec;53(6):1037-42 - PubMed
  176. Neurobiol Aging. 1996 Mar-Apr;17(2):269-73 - PubMed
  177. Atherosclerosis. 1980 Apr;35(4):439-49 - PubMed
  178. J Neurochem. 2007 Nov;103(4):1285-92 - PubMed
  179. Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):196-201 - PubMed

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