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Monacelli F, Odetti P, Sartini M, et al. Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal. Dement Geriatr Cogn Dis Extra. 2014;4(1):45-50doi: 10.1159/000357124.
Monacelli, F., Odetti, P., Sartini, M., Parodi, A., Brunelli, C., & Rosa, G. (2014). Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal. Dementia and geriatric cognitive disorders extra, 4(1), 45-50. https://doi.org/10.1159/000357124
Monacelli, Fiammetta, et al. "Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal." Dementia and geriatric cognitive disorders extra vol. 4,1 (2014): 45-50. doi: https://doi.org/10.1159/000357124
Monacelli F, Odetti P, Sartini M, Parodi A, Brunelli C, Rosa G. Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal. Dement Geriatr Cogn Dis Extra. 2014 Feb 14;4(1):45-50. doi: 10.1159/000357124. eCollection 2014 Jan. PMID: 24711813; PMCID: PMC3977226.
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Dement Geriatr Cogn Dis Extra. 2014 Feb 14;4(1):45-50. doi: 10.1159/000357124. eCollection 2014 Jan.

Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal.

Dementia and geriatric cognitive disorders extra

Fiammetta Monacelli, Patrizio Odetti, Marina Sartini, Antonello Parodi, Claudio Brunelli, Gianmarco Rosa

Affiliations

  1. Sections of Geriatrics, Department of Internal Medicine and Medical Specialties (DiMI), Genoa, Italy.
  2. Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  3. Sections of Cardiology, Department of Internal Medicine and Medical Specialties (DiMI), Genoa, Italy.

PMID: 24711813 PMCID: PMC3977226 DOI: 10.1159/000357124

Abstract

BACKGROUND/AIM: Traditional risk factors, like impaired transmitral flow in diastolic filling [vortex formation time (VFT) as echocardiographic parameter], contribute to Alzheimer's disease (AD). Moreover, we observed that acetylcholinesterase inhibitors provide a significant cardioprotection. We assessed the pathogenetic role of VFT as early cardiovascular risk factor in 23 AD patients and 24 controls.

RESULTS: The results showed no statistical difference between the two groups, but the VFT values were significantly lower in nontreated AD patients, and higher value were observed in AD patients treated with anticholinesterases.

CONCLUSIONS: The results support the beneficial effects of anticholinesterases on the cardiovascular system of AD patients. Thus, the transition to evidence-based medicine and an in vivo model of cardiomyocytes might strengthen these results.

Keywords: Alzheimer's disease; Anticholinesterase therapy; Cardiovascular protection; Diastolic dysfunction; Vortex formation index

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