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Jacociunas LV, Dihl RR, Lehmann M, et al. Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster. Genet Mol Biol. 2013;37(1):90-104doi: 10.1590/s1415-47572014000100015.
Jacociunas, L. V., Dihl, R. R., Lehmann, M., de Barros Falcão Ferraz, A., Richter, M. F., da Silva, J., & de Andrade, H. H. (2014). Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster. Genetics and molecular biology, 37(1), 90-104. https://doi.org/10.1590/s1415-47572014000100015
Jacociunas, Laura Vicedo, et al. "Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster." Genetics and molecular biology vol. 37,1 (2014): 90-104. doi: https://doi.org/10.1590/s1415-47572014000100015
Jacociunas LV, Dihl RR, Lehmann M, de Barros Falcão Ferraz A, Richter MF, da Silva J, de Andrade HH. Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster. Genet Mol Biol. 2014 Mar;37(1):90-104. doi: 10.1590/s1415-47572014000100015. Epub 2013 Feb 28. PMID: 24688296; PMCID: PMC3958332.
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Genet Mol Biol. 2014 Mar;37(1):90-104. doi: 10.1590/s1415-47572014000100015. Epub 2013 Feb 28.

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster.

Genetics and molecular biology

Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade

Affiliations

  1. Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, Canoas, RS, Brazil .
  2. Programa de Pós-Graduação em Genética e Toxicologia Aplicada, Universidade Luterana do Brasil, Canoas, RS, Brazil . ; Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde, Universidade Luterana do Brasil, Canoas, RS, Brazil .
  3. Curso de Biologia Marinha e Costeira, Universidade Estadual do Rio Grande do Sul, Porto Alegre, RS, Brazil .
  4. Laboratório de Estomatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil .

PMID: 24688296 PMCID: PMC3958332 DOI: 10.1590/s1415-47572014000100015

Abstract

The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the intercalating agent bleomycin (BLM), were examined using the somatic mutation and recombination test (SMART) in Drosophila melanogaster. Neither the mutagenicity nor the recombinogenicity of BLM or MMC was modified by co- or post-treatment with BHE or LE. In contrast, co-treatment with BHE significantly enhanced the EMS-induced genotoxicity involving mutagenic and/or recombinant events. Co-treatment with LE did not alter the genotoxicity of EMS whereas post-treatment with the highest dose of LE significantly increased this genotoxicity. This enhancement included a synergistic increase restricted to somatic recombination. These results show that artichoke extracts promote homologous recombination in proliferative cells of D. melanogaster.

Keywords: Drosophila melanogaster; SMART; artichoke; recombinogenicity

References

  1. Exp Mol Pathol. 2003 Apr;74(2):94-105 - PubMed
  2. Toxicol In Vitro. 1997 Oct;11(5):669-72 - PubMed
  3. Ceska Slov Farm. 2001 Nov;50(6):277-9 - PubMed
  4. Mutat Res. 1992 May 1;279(1):21-33 - PubMed
  5. Mutat Res. 1992 Feb;271(1):59-67 - PubMed
  6. Environ Mol Mutagen. 2004;44(5):394-400 - PubMed
  7. Mutat Res. 1989 Sep;214(1):69-80 - PubMed
  8. J Nat Prod. 1987 Jul-Aug;50(4):612-7 - PubMed
  9. Free Radic Biol Med. 1997;22(5):749-60 - PubMed
  10. Mutat Res. 1987 Feb;190(2):107-12 - PubMed
  11. Life Sci. 2002 Nov 1;71(24):2897-08 - PubMed
  12. Chem Biol. 1995 Sep;2(9):575-9 - PubMed
  13. In Vivo. 1994 Nov-Dec;8(6):1095-8 - PubMed
  14. Phytomedicine. 1997 Dec;4(4):369-78 - PubMed
  15. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:53-6 - PubMed
  16. Carcinogenesis. 1986 Jun;7(6):959-63 - PubMed
  17. Mutat Res. 1988 Aug;203(4):297-308 - PubMed
  18. Mutat Res. 1970 May;9(5):527-49 - PubMed
  19. Cancer Lett. 1995 Nov 6;97(2):255-61 - PubMed
  20. Environ Mol Mutagen. 2002;40(4):266-76 - PubMed
  21. J Ethnopharmacol. 2003 Jun;86(2-3):203-11 - PubMed
  22. Mutat Res. 2011 Nov 27;726(1):60-5 - PubMed
  23. J Agric Food Chem. 2006 Nov 15;54(23):8812-7 - PubMed
  24. Neoplasma. 2001;48(2):104-7 - PubMed
  25. Environ Mutagen. 1984;6(2):153-88 - PubMed
  26. Food Chem Toxicol. 2013 May;55:56-9 - PubMed
  27. Mutat Res. 1995 Apr;334(2):247-58 - PubMed
  28. J Agric Food Chem. 2003 Jan 29;51(3):601-8 - PubMed
  29. J Med Food. 2012 Oct;15(10):873-8 - PubMed
  30. Mutagenesis. 1994 Jul;9(4):383-6 - PubMed
  31. Mutat Res. 2006 Sep 5;607(2):225-30 - PubMed
  32. Mutat Res. 1991 Mar;257(2):127-43 - PubMed
  33. Phytomedicine. 1994 Sep;1(2):107-15 - PubMed
  34. Mutat Res. 1999 Aug 18;444(2):355-65 - PubMed
  35. Nutr Res Rev. 2000 Jun;13(1):79-106 - PubMed
  36. Phytother Res. 2008 Jan;22(1):77-81 - PubMed
  37. J Agric Food Chem. 2004 Dec 1;52(24):7272-8 - PubMed
  38. Mutat Res. 1990 Mar;240(3):209-16 - PubMed
  39. J Pharmacol Exp Ther. 1998 Sep;286(3):1122-8 - PubMed
  40. Phytother Res. 2002 Jun;16(4):368-72 - PubMed
  41. Bioorg Med Chem Lett. 2003 Jan 20;13(2):223-8 - PubMed

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