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Razani M, Luk TW, Mariampillai A, et al. Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples. Biomed Opt Express. 2014;5(3):895-906doi: 10.1364/BOE.5.000895.
Razani, M., Luk, T. W., Mariampillai, A., Siegler, P., Kiehl, T. R., Kolios, M. C., & Yang, V. X. (2014). Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples. Biomedical optics express, 5(3), 895-906. https://doi.org/10.1364/BOE.5.000895
Razani, Marjan, et al. "Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples." Biomedical optics express vol. 5,3 (2014): 895-906. doi: https://doi.org/10.1364/BOE.5.000895
Razani M, Luk TW, Mariampillai A, Siegler P, Kiehl TR, Kolios MC, Yang VX. Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples. Biomed Opt Express. 2014 Feb 26;5(3):895-906. doi: 10.1364/BOE.5.000895. eCollection 2014 Mar 01. PMID: 24688822; PMCID: PMC3959849.
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Biomed Opt Express. 2014 Feb 26;5(3):895-906. doi: 10.1364/BOE.5.000895. eCollection 2014 Mar 01.

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples.

Biomedical optics express

Marjan Razani, Timothy W H Luk, Adrian Mariampillai, Peter Siegler, Tim-Rasmus Kiehl, Michael C Kolios, Victor X D Yang

Affiliations

  1. Department of Physics, Ryerson University, Toronto, Canada.
  2. Department of Electrical and Computer Engineering, Ryerson University, Toronto, Canada.
  3. Department of Pathology, University Health Network, Toronto, Ontario Canada ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.
  4. Department of Physics, Ryerson University, Toronto, Canada ; [email protected].
  5. Department of Physics, Ryerson University, Toronto, Canada ; Department of Electrical and Computer Engineering, Ryerson University, Toronto, Canada ; Division of Neurosurgery, University of Toronto, Toronto, Canada.

PMID: 24688822 PMCID: PMC3959849 DOI: 10.1364/BOE.5.000895

Abstract

In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, synchronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were composed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in gel. Differential OCT phase maps, measured with and without the ARF, detected the microscopic displacement generated by shear wave propagation in these phantoms and samples of different stiffness. We present the technique for calculating tissue mechanical properties by propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. This method lays the foundation for future in-vitro and in-vivo studies of mechanical property measurements of biological tissues such as vascular tissues, where normal and pathological structures may exhibit significant contrast in the shear modulus.

Keywords: (170.4500) Optical coherence tomography; (170.6935) Tissue characterization

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