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Rincon F, Wright CB. Current pathophysiological concepts in cerebral small vessel disease. Front Aging Neurosci. 2014;6:24doi: 10.3389/fnagi.2014.00024.
Rincon, F., & Wright, C. B. (2014). Current pathophysiological concepts in cerebral small vessel disease. Frontiers in aging neuroscience, 624. https://doi.org/10.3389/fnagi.2014.00024
Rincon, Fred, and Wright, Clinton B. "Current pathophysiological concepts in cerebral small vessel disease." Frontiers in aging neuroscience vol. 6 (2014): 24. doi: https://doi.org/10.3389/fnagi.2014.00024
Rincon F, Wright CB. Current pathophysiological concepts in cerebral small vessel disease. Front Aging Neurosci. 2014 Mar 24;6:24. doi: 10.3389/fnagi.2014.00024. eCollection 2014. PMID: 24715862; PMCID: PMC3970024.
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Front Aging Neurosci. 2014 Mar 24;6:24. doi: 10.3389/fnagi.2014.00024. eCollection 2014.

Current pathophysiological concepts in cerebral small vessel disease.

Frontiers in aging neuroscience

Fred Rincon, Clinton B Wright

Affiliations

  1. Department of Neurology, Thomas Jefferson University Philadelphia, PA, USA.
  2. Department of Neurosurgery, Thomas Jefferson University Philadelphia, PA, USA ; Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami Miami, FL, USA ; Department of Epidemiology and Public Health, University of Miami Miami, FL, USA ; Neuroscience Program, University of Miami Miami, FL, USA.

PMID: 24715862 PMCID: PMC3970024 DOI: 10.3389/fnagi.2014.00024

Abstract

The association between cerebral small vessel disease (SVD) - in the form of white matter lesions, infarctions, and hemorrhages - with vascular cognitive impairment (VCI), has mostly been deduced from observational studies. Pathological conditions affecting the small vessels of the brain and leading to SVD have suggested plausible molecular mechanisms involved in vascular damage and their impact on brain function. However, much still needs to be clarified in understanding the pathophysiology of VCI, the role of neurodegenerative processes such as Alzheimer's disease, and the impact of aging itself. In addition, both genetic predispositions and environmental exposures may potentiate the development of SVD and interact with normal aging to impact cognitive function and require further study. Advances in technology, in the analysis of genetic and epigenetic data, neuroimaging such as magnetic resonance imaging, and new biomarkers will help to clarify the complex factors leading to SVD and the expression of VCI.

Keywords: Alzheimer’s disease; leukoaraiosis; silent brain infarction; stroke; vascular cognitive impairment

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