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Barrera-Maldonado CD, Wiener I, Sim S. Clear cell adenocarcinoma of the colon: a case report and review of the literature. Case Rep Oncol Med. 2014;2014:905478doi: 10.1155/2014/905478.
Barrera-Maldonado, C. D., Wiener, I., & Sim, S. (2014). Clear cell adenocarcinoma of the colon: a case report and review of the literature. Case reports in oncological medicine, 2014905478. https://doi.org/10.1155/2014/905478
Barrera-Maldonado, Christian Daniel, et al. "Clear cell adenocarcinoma of the colon: a case report and review of the literature." Case reports in oncological medicine vol. 2014 (2014): 905478. doi: https://doi.org/10.1155/2014/905478
Barrera-Maldonado CD, Wiener I, Sim S. Clear cell adenocarcinoma of the colon: a case report and review of the literature. Case Rep Oncol Med. 2014;2014:905478. doi: 10.1155/2014/905478. Epub 2014 Mar 04. PMID: 24716050; PMCID: PMC3970243.
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Case Rep Oncol Med. 2014;2014:905478. doi: 10.1155/2014/905478. Epub 2014 Mar 04.

Clear cell adenocarcinoma of the colon: a case report and review of the literature.

Case reports in oncological medicine

Christian Daniel Barrera-Maldonado, Isidoro Wiener, Sue Sim

Affiliations

  1. Department of Graduate Medical Education, Memorial Hermann Memorial City, 921 N Gessner Road, Houston, TX 77024, USA.
  2. General and Vascular Surgery, 902 Frostwood Suite 205, Prof. Building 1, Houston, TX 77024, USA.
  3. Department of Pathology, Memorial Hermann Memorial City, 921 N Gessner Road, Houston, TX 77024, USA.

PMID: 24716050 PMCID: PMC3970243 DOI: 10.1155/2014/905478

Abstract

Clear cell adenocarcinoma of the colon has been described scarcely in the literature. It affects elderly men more commonly than women and usually appears in the left side of the colon. A Hispanic 41-year-old female came to the emergency room with abdominal pain, vomiting, and distension. Physical exam revealed generalized tenderness without peritoneal signs. Laboratory data was unremarkable. A CT scan showed an apple-core lesion in the distal colon. A flexible sigmoidoscopy revealed an obstructive mass that made further evaluation impossible. Exploratory surgery revealed a hard mass obstructing the descending colon, which was resected. Histopathology analysis with immunohistochemistry staining was positive for cytokeratin 20, cytokeratin 10, CDX2, and villin, while it was negative for cytokeratin 7, RCC, vimentin, and CD31. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arise from the kidneys and Müllerian organs. Immunohistochemistry is crucial for establishing the origin of these neoplastic cells. A cytokeratin 20+/7- with positive CDX2 is highly specific and sensitive for intestinal neoplastic origin. The main treatment has been surgery alone with moderately good results. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.

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