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Buğdacı MS, Yanardağ H, Ar MC, et al. Pulmonary radiological findings in patients with acute myeloid leukemia and their relationship to chemotherapy and prognosis: a single-center retrospective study. Turk J Haematol. 2012;29(3):217-22doi: 10.5152/tjh.2011.77.
Buğdacı, M. S., Yanardağ, H., Ar, M. C., Soysal, T., Coşkun, S., & Demirci, S. (2012). Pulmonary radiological findings in patients with acute myeloid leukemia and their relationship to chemotherapy and prognosis: a single-center retrospective study. Turkish journal of haematology : official journal of Turkish Society of Haematology, 29(3), 217-22. https://doi.org/10.5152/tjh.2011.77
Buğdacı, Mehmet S, et al. "Pulmonary radiological findings in patients with acute myeloid leukemia and their relationship to chemotherapy and prognosis: a single-center retrospective study." Turkish journal of haematology : official journal of Turkish Society of Haematology vol. 29,3 (2012): 217-22. doi: https://doi.org/10.5152/tjh.2011.77
Buğdacı MS, Yanardağ H, Ar MC, Soysal T, Coşkun S, Demirci S. Pulmonary radiological findings in patients with acute myeloid leukemia and their relationship to chemotherapy and prognosis: a single-center retrospective study. Turk J Haematol. 2012 Sep;29(3):217-22. doi: 10.5152/tjh.2011.77. Epub 2012 Sep 15. PMID: 24744664; PMCID: PMC3986745.
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Turk J Haematol. 2012 Sep;29(3):217-22. doi: 10.5152/tjh.2011.77. Epub 2012 Sep 15.

Pulmonary radiological findings in patients with acute myeloid leukemia and their relationship to chemotherapy and prognosis: a single-center retrospective study.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Mehmet S Buğdacı, Halil Yanardağ, M Cem Ar, Teoman Soysal, Süleyman Coşkun, Sabriye Demirci

Affiliations

  1. ?stanbul University, Cerrahpa?a School of Medicine, Department of Pneumophysiology, Division of Internal Medicine, ?stanbul, Turkey.
  2. ?stanbul Training and Research Hospital, Department of Hematology, ?stanbul, Turkey.
  3. ?stanbul University, Cerrahpa?a School of Medicine, Department of Hematology, Division of Internal Medicine, ?stanbul, Turkey.

PMID: 24744664 PMCID: PMC3986745 DOI: 10.5152/tjh.2011.77

Abstract

OBJECTIVE: Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Pulmonary are among the most common causes of mortality in AML. This single-center retrospective study aimed to evaluate the relationship between radiological findings of pulmonary at presentation and post chemotherapy on prognosis and clinical outcome in a group of AML patients.

MATERIAL AND METHODS: The study included 278 AML patients. Clinical and radiological findings, laboratory findings, and microbiological culture results were evaluated. Pulmonary complications at presentation and post chemotherapy were compared.

RESULTS: Pulmonary complications were observed in 53 of the patients (19%). Mean age of the patients with and without pulmonary complications was 43.1 ± 15.2 years and 38.8 ± 16.3 years, respectively (P < 0.001). Pulmonary complications were not correlated with gender, AML subtype, or the serum lactate dehydrogenase (LDH) level. The most common cause of pulmonary complications was infection. Pulmonary complications were observed in 29% and 71% of the patients at presentation and post chemotherapy, respectively.

CONCLUSION: Pulmonary complications were observed more frequently at presentation in neutropenic AML patients of advanced age. The mortality rate was higher among the AML patients that had pulmonary complications at presentation.

Keywords: Acute myeloid leukemia; Pulmonary disease; Radiological findings

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