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Gibbs ME, Hertz L. Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick. Front Pharmacol. 2014;5:54doi: 10.3389/fphar.2014.00054.
Gibbs, M. E., & Hertz, L. (2014). Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick. Frontiers in pharmacology, 554. https://doi.org/10.3389/fphar.2014.00054
Gibbs, Marie E, and Hertz, Leif. "Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick." Frontiers in pharmacology vol. 5 (2014): 54. doi: https://doi.org/10.3389/fphar.2014.00054
Gibbs ME, Hertz L. Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick. Front Pharmacol. 2014 Apr 01;5:54. doi: 10.3389/fphar.2014.00054. eCollection 2014. PMID: 24744730; PMCID: PMC3978258.
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Front Pharmacol. 2014 Apr 01;5:54. doi: 10.3389/fphar.2014.00054. eCollection 2014.

Serotonin mediation of early memory formation via 5-HT2B receptor-induced glycogenolysis in the day-old chick.

Frontiers in pharmacology

Marie E Gibbs, Leif Hertz

Affiliations

  1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University Parkville, VIC, Australia.
  2. Department of Clinical Pharmacology, China Medical University Shenyang, China.

PMID: 24744730 PMCID: PMC3978258 DOI: 10.3389/fphar.2014.00054

Abstract

Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5-HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and inhibition at higher doses. The non-selective 5-HT receptor antagonist methiothepin and the selective 5-HT2B/C receptor antagonist SB221284 both inhibited memory, suggesting actions of serotonin on at least two different receptor subtypes. The 5-HT2B/C and astrocyte-specific 5-HT receptor agonist, fluoxetine and paroxetine, enhanced memory and the effect was attributed to glycogenolysis. Inhibition of glycogenolysis with a low dose of DAB (1,4-dideoxy-1,4-imino-D-arabinitol) prevented both serotonin and fluoxetine from enhancing memory during short-term memory but not during intermediate memory. The role of serotonin on the 5-HT2B/C receptor appears to involve glycogen breakdown in astrocytes during short-term memory, whereas other published evidence attributes the second period of glycogenolysis to noradrenaline.

Keywords: astrocytes; day-old chick; glycogenolysis; memory formation; serotonin

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