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Ksionda O, Limnander A, Roose JP. RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing). 2013;8(5):508-532doi: 10.1007/s11515-013-1276-9.
Ksionda, O., Limnander, A., & Roose, J. P. (2013). RasGRP Ras guanine nucleotide exchange factors in cancer. Frontiers in biology, 8(5), 508-532. https://doi.org/10.1007/s11515-013-1276-9
Ksionda, Olga, et al. "RasGRP Ras guanine nucleotide exchange factors in cancer." Frontiers in biology vol. 8,5 (2013): 508-532. doi: https://doi.org/10.1007/s11515-013-1276-9
Ksionda O, Limnander A, Roose JP. RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing). 2013 Oct 01;8(5):508-532. doi: 10.1007/s11515-013-1276-9. PMID: 24744772; PMCID: PMC3987922.
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Front Biol (Beijing). 2013 Oct 01;8(5):508-532. doi: 10.1007/s11515-013-1276-9.

RasGRP Ras guanine nucleotide exchange factors in cancer.

Frontiers in biology

Olga Ksionda, Andre Limnander, Jeroen P Roose

Affiliations

  1. Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

PMID: 24744772 PMCID: PMC3987922 DOI: 10.1007/s11515-013-1276-9

Abstract

RasGRP proteins are activators of Ras and other related small GTPases by the virtue of functioning as guanine nucleotide exchange factors (GEFs). In vertebrates, four RasGRP family members have been described. RasGRP-1 through -4 share many structural domains but there are also subtle differences between each of the different family members. Whereas SOS RasGEFs are ubiquitously expressed, RasGRP proteins are expressed in distinct patterns, such as in different cells of the hematopoietic system and in the brain. Most studies have concentrated on the role of RasGRP proteins in the development and function of immune cell types because of the predominant RasGRP expression profiles in these cells and the immune phenotypes of mice deficient for

Keywords: Ras; RasGRP; cancer; lymphocytes; receptor; signaling

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