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Gacci M, Baldi E, Tamburrino L, et al. Quality of Life and Sexual Health in the Aging of PCa Survivors. Int J Endocrinol. 2014;2014:470592doi: 10.1155/2014/470592.
Gacci, M., Baldi, E., Tamburrino, L., Detti, B., Livi, L., De Nunzio, C., Tubaro, A., Gravas, S., Carini, M., & Serni, S. (2014). Quality of Life and Sexual Health in the Aging of PCa Survivors. International journal of endocrinology, 2014470592. https://doi.org/10.1155/2014/470592
Gacci, Mauro, et al. "Quality of Life and Sexual Health in the Aging of PCa Survivors." International journal of endocrinology vol. 2014 (2014): 470592. doi: https://doi.org/10.1155/2014/470592
Gacci M, Baldi E, Tamburrino L, Detti B, Livi L, De Nunzio C, Tubaro A, Gravas S, Carini M, Serni S. Quality of Life and Sexual Health in the Aging of PCa Survivors. Int J Endocrinol. 2014;2014:470592. doi: 10.1155/2014/470592. Epub 2014 Mar 17. PMID: 24744780; PMCID: PMC3976934.
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Int J Endocrinol. 2014;2014:470592. doi: 10.1155/2014/470592. Epub 2014 Mar 17.

Quality of Life and Sexual Health in the Aging of PCa Survivors.

International journal of endocrinology

Mauro Gacci, Elisabetta Baldi, Lara Tamburrino, Beatrice Detti, Lorenzo Livi, Cosimo De Nunzio, Andrea Tubaro, Stavros Gravas, Marco Carini, Sergio Serni

Affiliations

  1. Department of Urology, University of Florence, Careggi Hospital, Viale Gramsci 7, 50121 Florence, Italy.
  2. Department of Experimental and Clinical Biomedical Sciences, Section of Clinical Pathophysiology, University of Florence, Italy.
  3. Radiotherapy, University Hospital Careggi, University of Florence, Italy.
  4. Department of Urology, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.
  5. Department of Urology, University Hospital of Larissa, Larissa, Greece.

PMID: 24744780 PMCID: PMC3976934 DOI: 10.1155/2014/470592

Abstract

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual hormones for PCa growth and progression has been established. However, several trials on androgens and PCa are recently focused on urinary continence, quality of life, and sexual function, suggesting a new point of view on the whole endocrinological aspect of PCa. During aging, metabolic syndrome, including diabetes, hypertension, dyslipidemia, and central obesity, can be associated with a chronic, low-grade inflammation of the prostate and with changes in the sex steroid pathways. These factors may affect both the carcinogenesis processes and treatment outcomes of PCa. Any treatment for PCa can have a long-lasting negative impact on quality of life and sexual health, which should be assessed by validated self-reported questionnaires. In particular, sexual health, urinary continence, and bowel function can be worsened after prostatectomy, radiotherapy, or hormone treatment, mostly in the elderly population. In the present review we summarized the current knowledge on the role of hormones, metabolic features, and primary treatments for PCa on the quality of life and sexual health of elderly Pca survivors.

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