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Woods GM, Bajwa RP, Kahwash SB, et al. Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case Rep Med. 2014;2014:473297doi: 10.1155/2014/473297.
Woods, G. M., Bajwa, R. P., Kahwash, S. B., & Guinipero, T. (2014). Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case reports in medicine, 2014473297. https://doi.org/10.1155/2014/473297
Woods, Gary M, et al. "Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm." Case reports in medicine vol. 2014 (2014): 473297. doi: https://doi.org/10.1155/2014/473297
Woods GM, Bajwa RP, Kahwash SB, Guinipero T. Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm. Case Rep Med. 2014;2014:473297. doi: 10.1155/2014/473297. Epub 2014 Mar 18. PMID: 24744787; PMCID: PMC3976921.
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Case Rep Med. 2014;2014:473297. doi: 10.1155/2014/473297. Epub 2014 Mar 18.

Secondary Acute Myeloid Leukemia in a One-Year-Old Girl Diagnosed with JAK2-V617F Mutation Positive Myeloproliferative Neoplasm.

Case reports in medicine

Gary M Woods, Rajinder P S Bajwa, Samir B Kahwash, Terri Guinipero

Affiliations

  1. Department of Hematology/Oncology/BMT, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
  2. Department of Hematology/Oncology/BMT, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.
  3. Department of Pathology, Nationwide Children's Hospital, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.

PMID: 24744787 PMCID: PMC3976921 DOI: 10.1155/2014/473297

Abstract

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by hyperproliferation of hematologic cell lines and have been associated with tyrosine kinase JAK2-V617F mutations. Secondary acute myeloid leukemia (sAML) is a known complication of JAK2-V617F+ MPNs and bears a poor prognosis. Although the evolution of a JAK2-V617F+ MPN to a mixed-lineage leukemia has been reported in the pediatric population, no evolutions into sAML have been described. We present a case of a one-year-old girl diagnosed with JAK2-V617F+ MPN with evolution into sAML. Despite initial morphologic remission, she eventually relapsed and succumbed to her disease.

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