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Org Lett. 2014 May 02;16(9):2538-41. doi: 10.1021/ol500918t. Epub 2014 Apr 11.

Directed additions of 2-arylpyridines and related substrates to cyclic imines through rhodium-catalyzed C-H functionalization.

Organic letters

Kanniyappan Parthasarathy, Ane Rebolledo Azcargorta, Ying Cheng, Carsten Bolm

Affiliations

  1. Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, 52056 Aachen, Germany.

PMID: 24720665 DOI: 10.1021/ol500918t

Abstract

Rhodium-catalyzed C-H functionalizations have been used for ortho-directed additions of 2-arylpyridines and (hetero)aryl-substituted pyrimidines, isoquinolines, and benzo[h]quinolones to cyclic imines. The resulting amino-functionalized products are formed in good to high yields.

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