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Furukawa J, Miyake H, Sakai I, et al. Significance of ureteroscopic biopsy grade in patients with upper tract urothelial carcinoma. Curr Urol. 2012;6(3):156-9doi: 10.1159/000343531.
Furukawa, J., Miyake, H., Sakai, I., & Fujisawa, M. (2013). Significance of ureteroscopic biopsy grade in patients with upper tract urothelial carcinoma. Current urology, 6(3), 156-9. https://doi.org/10.1159/000343531
Furukawa, Junya, et al. "Significance of ureteroscopic biopsy grade in patients with upper tract urothelial carcinoma." Current urology vol. 6,3 (2013): 156-9. doi: https://doi.org/10.1159/000343531
Furukawa J, Miyake H, Sakai I, Fujisawa M. Significance of ureteroscopic biopsy grade in patients with upper tract urothelial carcinoma. Curr Urol. 2013 Jan;6(3):156-9. doi: 10.1159/000343531. Epub 2012 Dec 21. PMID: 24917735; PMCID: PMC3783279.
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Curr Urol. 2013 Jan;6(3):156-9. doi: 10.1159/000343531. Epub 2012 Dec 21.

Significance of ureteroscopic biopsy grade in patients with upper tract urothelial carcinoma.

Current urology

Junya Furukawa, Hideaki Miyake, Iori Sakai, Masato Fujisawa

Affiliations

  1. Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

PMID: 24917735 PMCID: PMC3783279 DOI: 10.1159/000343531

Abstract

BACKGROUND: The objective of this study was to assess the significance of the ureteroscopic biopsy grade for patients with upper tract urothelial carcinoma (UTUC).

PATIENTS AND METHODS: This study included 40 patients who were diagnosed with a single focus of UTUC by ureteroscopic biopsy and subsequently underwent nephroureterectomy. The significance of the biopsy grade as a predictive factor for pathological outcomes of nephroureterectomy was retrospectively analyzed.

RESULTS: Of these 40 patients, 19 (47.5%) and 21 (52.5%) were diagnosed with low and high grade UTUC, respectively. The ureteroscopic biopsy grade matched the pathological grade of surgically resected specimens in 35 of the 40 cases (87.5%), and there was a significant correlation between the biopsy and pathological grades (p < 0.001). Furthermore, the biopsy grade was also shown to be closely associated with the pathological stage (p < 0.001); that is, only 1 of the 19 patients (5.3%) with biopsy low grade UTUC were pathologically diagnosed as having muscle invasive disease, while 17 of the 21 patients (81.0%) with biopsy high grade UTUC appeared to show tumor invasion into muscle or deeper.

CONCLUSIONS: The grade of UTUC on ureteroscopic biopsy could provide accurate diagnostic information on the final pathology of nephroureterectomy specimens.

Keywords: Upper tract urothelial carcinoma; Ureteroscopic biopsy; Urinary cytology

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