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Lopatina O, Yoshihara T, Nishimura T, et al. Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Front Behav Neurosci. 2014;8:133doi: 10.3389/fnbeh.2014.00133.
Lopatina, O., Yoshihara, T., Nishimura, T., Zhong, J., Akther, S., Fakhrul, A. A., Liang, M., Higashida, C., Sumi, K., Furuhara, K., Inahata, Y., Huang, J. J., Koizumi, K., Yokoyama, S., Tsuji, T., Petugina, Y., Sumarokov, A., Salmina, A. B., Hashida, K., Kitao, Y., Hori, O., Asano, M., Kitamura, Y., Kozaka, T., Shiba, K., Zhong, F., Xie, M. J., Sato, M., Ishihara, K., & Higashida, H. (2014). Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Frontiers in behavioral neuroscience, 8133. https://doi.org/10.3389/fnbeh.2014.00133
Lopatina, Olga, et al. "Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease." Frontiers in behavioral neuroscience vol. 8 (2014): 133. doi: https://doi.org/10.3389/fnbeh.2014.00133
Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H. Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Front Behav Neurosci. 2014 Apr 22;8:133. doi: 10.3389/fnbeh.2014.00133. eCollection 2014. PMID: 24795584; PMCID: PMC4001052.
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Front Behav Neurosci. 2014 Apr 22;8:133. doi: 10.3389/fnbeh.2014.00133. eCollection 2014.

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.

Frontiers in behavioral neuroscience

Olga Lopatina, Toru Yoshihara, Tomoko Nishimura, Jing Zhong, Shirin Akther, Azam A K M Fakhrul, Mingkun Liang, Chiharu Higashida, Kohei Sumi, Kazumi Furuhara, Yuki Inahata, Jian-Jung Huang, Keita Koizumi, Shigeru Yokoyama, Takahiro Tsuji, Yulia Petugina, Andrei Sumarokov, Alla B Salmina, Koji Hashida, Yasuko Kitao, Osamu Hori, Masahide Asano, Yoji Kitamura, Takashi Kozaka, Kazuhiro Shiba, Fangfang Zhong, Min-Jue Xie, Makoto Sato, Katsuhiko Ishihara, Haruhiro Higashida

Affiliations

  1. Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  2. Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
  3. Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan.
  4. Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Core Research for Evolutional Science and Technology Tokyo, Japan.
  5. Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University Kanazawa, Japan ; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  6. Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  7. Core Research for Evolutional Science and Technology Tokyo, Japan ; Department of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences Kanazawa, Japan.
  8. Advanced Science Research Center, Kanazawa University Kanazawa, Japan.
  9. Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan.
  10. Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui Fukui, Japan ; Research Center for Child Mental Development, University of Fukui Fukui, Japan.
  11. Department of Immunology and Molecular Genetics, Kawasaki Medical School Kurashiki, Japan.

PMID: 24795584 PMCID: PMC4001052 DOI: 10.3389/fnbeh.2014.00133

Abstract

CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells. Although CD157/Bst1 is a risk locus in Parkinson's disease (PD), little is known about the function of CD157 in the nervous system and contribution to PD progression. Here, we show that no apparent motor dysfunction was observed in young knockout (CD157 (-/-)) male mice under less aging-related effects on behaviors. CD157 (-/-) mice exhibited anxiety-related and depression-like behaviors compared with wild-type mice. These behaviors were rescued through treatment with anti-psychiatric drugs and oxytocin. CD157 was weakly expressed in the amygdala and c-Fos immunoreactivity in the amygdala was less evident in CD157 (-/-) mice than in wild-type mice. These results demonstrate for the first time that CD157 plays a role as a neuro-regulator and suggest a potential role in pre-motor symptoms in PD.

Keywords: BST-1; emotion-related behavior; non-motor symptoms; oxytocin; social behavior

References

  1. Hum Mol Genet. 2011 Jan 15;20(2):345-53 - PubMed
  2. J Biol Chem. 2009 May 1;284(18):12550-61 - PubMed
  3. PLoS One. 2012;7(1):e29873 - PubMed
  4. Biochem Biophys Res Commun. 1996 Nov 21;228(3):838-45 - PubMed
  5. Horm Behav. 2012 Mar;61(3):392-9 - PubMed
  6. Am J Physiol Cell Physiol. 2007 Jan;292(1):C353-61 - PubMed
  7. Psychopharmacology (Berl). 1987;92(2):180-5 - PubMed
  8. Neurochem Int. 2012 Nov;61(6):828-38 - PubMed
  9. Nat Commun. 2013;4:1346 - PubMed
  10. Nature. 2007 Mar 1;446(7131):41-5 - PubMed
  11. Mov Disord. 2008 Jan 30;23(2):183-9; quiz 313 - PubMed
  12. Cochrane Database Syst Rev. 2011 Dec 07;(12):CD006528 - PubMed
  13. Cytometry B Clin Cytom. 2013 Jul-Aug;84(4):207-17 - PubMed
  14. Biochem Biophys Res Commun. 1996 Feb 27;219(3):941-6 - PubMed
  15. Immunol Lett. 1996 Dec 1;54(1):1-4 - PubMed
  16. Mol Brain. 2013 Sep 23;6:41 - PubMed
  17. Parkinsonism Relat Disord. 2012 Sep;18(8):958-63 - PubMed
  18. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):334-9 - PubMed
  19. Nat Nanotechnol. 2013 Sep;8(9):682-9 - PubMed
  20. Chin Med J (Engl). 2012 Feb;125(4):588-92 - PubMed
  21. Mov Disord. 2013 Nov;28(13):1892-5 - PubMed
  22. Lancet. 2011 Feb 19;377(9766):641-9 - PubMed
  23. Front Biosci (Landmark Ed). 2014 Jan 01;19:366-78 - PubMed
  24. Neuron. 2012 Feb 9;73(3):553-66 - PubMed
  25. Physiol Rev. 2008 Jul;88(3):841-86 - PubMed
  26. Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408 - PubMed
  27. Hum Mol Genet. 2011 Feb 1;20(3):615-27 - PubMed
  28. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1983-8 - PubMed
  29. Am J Geriatr Psychiatry. 2013 Jun;21(6):520-8 - PubMed
  30. Mov Disord. 2010 Oct 15;25(13):2105-13 - PubMed
  31. Eur J Hum Genet. 2011 Jun;19(6):655-61 - PubMed
  32. J Biol Chem. 2011 May 27;286(21):18681-91 - PubMed
  33. Neurobiol Aging. 2013 Nov;34(11):2695.e1-7 - PubMed
  34. Sci Rep. 2013 Dec 06;3:3440 - PubMed
  35. Parkinsonism Relat Disord. 2010 Dec;16(10):656-60 - PubMed
  36. J Neuroendocrinol. 2013 Jul;25(7):655-67 - PubMed
  37. Blood. 2004 Dec 15;104(13):4269-78 - PubMed
  38. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5325-9 - PubMed
  39. Front Behav Neurosci. 2013 Nov 26;7:175 - PubMed
  40. Mov Disord. 2011 Aug 1;26(9):1677-83 - PubMed
  41. BMC Med Genet. 2011 Aug 03;12:104 - PubMed
  42. Eur J Neurosci. 2003 Jan;17(1):1-12 - PubMed
  43. J Clin Invest. 1998 Aug 1;102(3):606-18 - PubMed
  44. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1309-17 - PubMed
  45. Lancet Neurol. 2009 May;8(5):464-74 - PubMed
  46. J Natl Cancer Inst. 2010 Aug 4;102(15):1160-77 - PubMed
  47. Science. 2004 Mar 26;303(5666):2007-10 - PubMed
  48. Nature. 2012 Jun 28;486(7404):490-5 - PubMed
  49. Parkinsonism Relat Disord. 2012 Aug;18(7):809-13 - PubMed
  50. Nat Genet. 2009 Dec;41(12):1303-7 - PubMed
  51. Neuropharmacology. 2012 Jan;62(1):115-24 - PubMed
  52. J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76 - PubMed
  53. Neurology. 2010 Aug 10;75(6):508-12 - PubMed
  54. Lancet. 2004 May 29;363(9423):1783-93 - PubMed
  55. Mol Med. 2006 Nov-Dec;12(11-12):334-41 - PubMed
  56. Psychopharmacology (Berl). 1985;85(3):367-70 - PubMed
  57. Neuropharmacology. 2012 Jun;62(7):2409-12 - PubMed
  58. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):423-40 - PubMed
  59. Curr Opin Neurol. 2011 Aug;24(4):318-23 - PubMed
  60. Parkinsonism Relat Disord. 2014 Mar;20(3):280-3 - PubMed
  61. Biol Psychiatry. 1993 Oct 1;34(7):465-70 - PubMed
  62. J Neurosci Res. 2008 Jul;86(9):2050-61 - PubMed
  63. Neuropharmacology. 2013 Jan;64:268-82 - PubMed
  64. Brain. 2002 Nov;125(Pt 11):2431-45 - PubMed
  65. PLoS One. 2013;8(1):e52396 - PubMed
  66. Methods Mol Biol. 2013;1016:39-56 - PubMed
  67. Neuron. 2010 Jun 10;66(5):646-61 - PubMed
  68. J Neurosci. 2009 Dec 9;29(49):15410-3 - PubMed
  69. FEBS Lett. 1994 Dec 19;356(2-3):244-8 - PubMed
  70. FEBS J. 2005 Sep;272(18):4590-7 - PubMed
  71. Neurology. 2012 Aug 14;79(7):659-67 - PubMed
  72. Mov Disord. 2012 Apr 15;27(5):608-16 - PubMed
  73. Parkinsonism Relat Disord. 2009 Feb;15(2):144-8 - PubMed
  74. J Neurol Sci. 2012 Dec 15;323(1-2):162-6 - PubMed
  75. Neuroscience. 2008 Oct 28;156(4):830-40 - PubMed
  76. Lancet Neurol. 2006 Mar;5(3):235-45 - PubMed
  77. Arch Int Pharmacodyn Ther. 1977 Oct;229(2):327-36 - PubMed
  78. Mov Disord. 2010 Jan 30;25(2):157-66 - PubMed
  79. Nature. 2013 Jan 24;493(7433):532-6 - PubMed
  80. Ann Neurol. 2012 Dec;72(6):893-901 - PubMed
  81. J Immunol. 1998 Oct 15;161(8):3974-83 - PubMed
  82. Chem Immunol. 2000;75:235-55 - PubMed
  83. Neurology. 2013 Feb 26;80(9):800-9 - PubMed
  84. Mov Disord. 2011 Feb 15;26(3):484-92 - PubMed
  85. JAMA Psychiatry. 2014 Feb;71(2):166-75 - PubMed
  86. Psychoneuroendocrinology. 2013 Oct;38(10):1985-93 - PubMed
  87. Front Behav Neurosci. 2014 Feb 14;8:31 - PubMed
  88. Horm Behav. 2012 Mar;61(3):351-8 - PubMed
  89. Adv Neurol. 2005;96:42-55 - PubMed
  90. Neuron. 2008 Mar 27;57(6):809-18 - PubMed
  91. J Biol Chem. 2005 Feb 18;280(7):5343-9 - PubMed
  92. Immunogenetics. 1999 Jul;49(7-8):597-604 - PubMed
  93. PLoS Genet. 2012;8(3):e1002548 - PubMed
  94. Am J Geriatr Psychiatry. 2014 Dec;22(12):1410-7 - PubMed
  95. Nat Rev Neurol. 2012 May 15;8(7):359-60 - PubMed
  96. J Neurosci. 2002 Oct 15;22(20):9099-103 - PubMed

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