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Kadakkuzha BM, Liu XA, Narvaez M, et al. Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity. Front Genet. 2014;5:84doi: 10.3389/fgene.2014.00084.
Kadakkuzha, B. M., Liu, X. A., Narvaez, M., Kaye, A., Akhmedov, K., & Puthanveettil, S. V. (2014). Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity. Frontiers in genetics, 584. https://doi.org/10.3389/fgene.2014.00084
Kadakkuzha, Beena M, et al. "Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity." Frontiers in genetics vol. 5 (2014): 84. doi: https://doi.org/10.3389/fgene.2014.00084
Kadakkuzha BM, Liu XA, Narvaez M, Kaye A, Akhmedov K, Puthanveettil SV. Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity. Front Genet. 2014 Apr 22;5:84. doi: 10.3389/fgene.2014.00084. eCollection 2014. PMID: 24795747; PMCID: PMC4001032.
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Front Genet. 2014 Apr 22;5:84. doi: 10.3389/fgene.2014.00084. eCollection 2014.

Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.

Frontiers in genetics

Beena M Kadakkuzha, Xin-An Liu, Maria Narvaez, Alexandra Kaye, Komolitdin Akhmedov, Sathyanarayanan V Puthanveettil

Affiliations

  1. Department of Neuroscience, The Scripps Research Institute Jupiter, FL, USA.

PMID: 24795747 PMCID: PMC4001032 DOI: 10.3389/fgene.2014.00084

Abstract

Despite the advances in our understanding of transcriptome, regulation and function of its non-coding components continue to be poorly understood. Here we searched for natural antisense transcript for sensorin (NAT-SRN), a neuropeptide expressed in the presynaptic sensory neurons of gill-withdrawal reflex of the marine snail Aplysia californica. Sensorin (SRN) has a key role in learning and long-term memory storage in Aplysia. We have now identified NAT-SRN in the central nervous system (CNS) and have confirmed its expression by northern blotting and fluorescent RNA in situ hybridization. Quantitative analysis of NAT-SRN in micro-dissected cell bodies and processes of sensory neurons suggest that NAT-SRN is present in the distal neuronal processes along with sense transcripts. Importantly, aging is associated with reduction in levels of NAT-SRN in sensory neuron processes. Furthermore, we find that forskolin, an activator of CREB signaling, differentially alters the distribution of SRN and NAT-SRN. These studies reveal novel insights into physiological regulation of natural antisense RNAs.

Keywords: Aplysia; aging; antisense RNA; memory; neural circuitry; nocoding RNA

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