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Manne V, Allen RM, Saab S. Strategies for the prevention of recurrent hepatitis B virus infection after liver transplantation. Gastroenterol Hepatol (N Y). 2014;10(3):175-9
Manne, V., Allen, R. M., & Saab, S. (2014). Strategies for the prevention of recurrent hepatitis B virus infection after liver transplantation. Gastroenterology & hepatology, 10(3), 175-9.
Manne, Vignan, et al. "Strategies for the prevention of recurrent hepatitis B virus infection after liver transplantation." Gastroenterology & hepatology vol. 10,3 (2014): 175-9.
Manne V, Allen RM, Saab S. Strategies for the prevention of recurrent hepatitis B virus infection after liver transplantation. Gastroenterol Hepatol (N Y). 2014 Mar;10(3):175-9. PMID: 24829544; PMCID: PMC4014049.
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Gastroenterol Hepatol (N Y). 2014 Mar;10(3):175-9.

Strategies for the prevention of recurrent hepatitis B virus infection after liver transplantation.

Gastroenterology & hepatology

Vignan Manne, Ruby M Allen, Sammy Saab

Affiliations

  1. Dr Manne and Ms Allen are research assistants in the Department of Surgery and Dr Saab is a professor of medicine and surgery in the Departments of Medicine and Surgery at the University of California, Los Angeles in Los Angeles, California.

PMID: 24829544 PMCID: PMC4014049

Abstract

Hepatitis B virus (HBV) infection is an international public health concern, and chronic infection can lead to the development of cirrhosis, liver failure, or hepatocellular carcinoma as well as the need for liver transplantation. The recurrence of HBV infection following liver transplantation was disproportionately high prior to the introduction of proper prophylactic treatment. Risk factors associated with the recurrence of HBV infection post-transplant include hepatitis B e antigen positivity, high levels of serum HBV DNA, and the presence of an antiviral drug-resistant strain prior to transplantation. The prevention of HBV recurrence began with the introduction of hepatitis B immunoglobulin (HBIG) in the early 1 990s. Nucleos(t)ide analog (NA) antiviral drugs were next to be introduced and, in combination with HBIG, are considered to be extremely effective for the prevention of recurrence. Because of concerns with HBIG, whether HBIG can be used for a short time or discontinued altogether is under debate. All of the NA antiviral drugs have been proven to be effective against HBV, at least in the pretransplant setting, and can be used safely posttransplant. Further investigation is still needed to standardize treatment in the posttransplant setting.

Keywords: Hepatitis B virus; hepatocellular carcinoma; liver transplantation; posttransplantation; prevention; risk factors

References

  1. Hepatology. 1991 Apr;13(4):619-26 - PubMed
  2. Hepatology. 2002 Jun;35(6):1528-35 - PubMed
  3. Dig Dis Sci. 2007 Oct;52(10):2497-500 - PubMed
  4. Liver Transpl. 2013 Jun;19(6):594-601 - PubMed
  5. Hepatology. 2008 Nov;48(5):1460-6 - PubMed
  6. Clin Transplant. 2007 Jul-Aug;21(4):510-7 - PubMed
  7. Hepatology. 1995 Jul;22(1):36-43 - PubMed
  8. Clin Liver Dis. 2005 May;9(2):191-211, v - PubMed
  9. Am J Transplant. 2011 Mar;11(3):511-7 - PubMed
  10. Liver Int. 2008 Jul;28(6):814-20 - PubMed
  11. J Viral Hepat. 2007 Nov;14 Suppl 1:37-44 - PubMed
  12. AIDS. 2006 Nov 14;20(17):2229-31 - PubMed
  13. Rev Med Virol. 2009 Jan;19(1):7-29 - PubMed
  14. Hepatology. 1996 Dec;24(6):1327-33 - PubMed
  15. Hepatology. 2003 Jul;38(1):86-95 - PubMed
  16. Transpl Int. 2008 Mar;21(3):234-46 - PubMed
  17. J Hepatol. 2001 Jun;34(6):903-10 - PubMed
  18. N Engl J Med. 1989 Oct 12;321(15):1014-22 - PubMed
  19. Gastroenterology. 2007 Mar;132(3):931-7 - PubMed
  20. J Hepatol. 2007 Oct;47(4):492-8 - PubMed
  21. Liver Transpl. 2007 Mar;13(3):349-60 - PubMed
  22. Liver Transpl. 2011 Oct;17(10):1176-90 - PubMed
  23. Liver Transpl. 2007 Mar;13(3):374-81 - PubMed
  24. Clin Transplant. 2006 Mar-Apr;20(2):206-10 - PubMed
  25. Gastroenterology. 2008 Jun;134(7):1890-9; quiz 2155 - PubMed
  26. Liver Int. 2008 Jan;28(1):72-8 - PubMed
  27. Liver Transpl. 2002 Jan;8(1):2-9 - PubMed
  28. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1627-31 - PubMed
  29. Transplantation. 1996 May 15;61(9):1358-64 - PubMed
  30. Hepatology. 1990 Aug;12(2):364-6 - PubMed
  31. Hepatology. 2011 Jan;53(1):62-72 - PubMed
  32. Am J Pathol. 1990 Sep;137(3):667-76 - PubMed
  33. Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):502-8 - PubMed
  34. World J Surg. 2013 Apr;37(4):812-9 - PubMed
  35. J Hepatol. 2006 Feb;44(2):283-90 - PubMed
  36. Gastroenterology. 2011 Oct;141(4):1212-9 - PubMed
  37. Liver Transpl. 2009 Nov;15(11):1525-34 - PubMed
  38. J Hepatol. 2003 Dec;39(6):1085-9 - PubMed
  39. J Hepatol. 1992 Jan;14(1):104-11 - PubMed
  40. N Engl J Med. 1993 Dec 16;329(25):1842-7 - PubMed
  41. Liver Transpl. 2005 Apr;11(4):402-9 - PubMed
  42. Am J Transplant. 2010 Aug;10(8):1823-33 - PubMed
  43. Liver Transpl. 2000 Jul;6(4):429-33 - PubMed
  44. Transpl Infect Dis. 2011 Jun;13(3):299-302 - PubMed
  45. Gastroenterology. 2003 Aug;125(2):292-7 - PubMed
  46. Virology. 1988 Dec;167(2):630-3 - PubMed
  47. Liver Transpl. 2013 Sep;19(9):1030-5 - PubMed
  48. Ther Adv Chronic Dis. 2013 Jul;4(4):157-66 - PubMed
  49. Gut. 1992 Oct;33(10):1390-6 - PubMed

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